Overexpression of MMP13 Is Associated with Clinical Outcomes and Poor Prognosis in Oral Squamous Cell Carcinoma

Table 4

Multivariate cox regression model analysis of MMP13 protein expression in OSCC overall survival.

Variables	Category	Number of patients (%)	Multivariate Logistic regression**
			OR	95% CI	value
Total		103
Protein expression of MMP13	Low	21 (20.4)	1.00^†	0.922–8.768	0.069
	High	82 (79.6)	2.84
Gender	Male	35 (34.0)	1.00^†	0.366–2.530	0.938
	Female	68 (66.0)	0.96
Age (years)	<45	11 (10.7)	1.00^†	0.127–2.997	0.548
	≥45	92 (89.3)	0.62
Smoking	No	81 (78.6)	1.00^†	0.150–2.017	0.367
	Yes	22 (21.4)	0.55
Drinking	No	71 (68.9)	1.00^†	0.376–1.656	0.531
	Yes	32 (31.1)	0.79
Betel quid chewing	No	49 (47.6)	1.00^†	0.195–1.178	0.109
	Yes	54 (52.4)	0.48
Tumor site	Non-tongue*	68 (66.0)	1.00^†	0.306–1.785	0.502
	Tongue	35 (34.0)	0.74
Lymph node metastasis***	Negative	57 (56.4)	1.00^†	0.771–4.188	0.175
	Positive	44 (43.6)	1.80
pTNM staging***	Early	38 (37.6)	1.00^†	0.662–4.683	0.257
	Advanced	63 (62.4)	1.76
Pattern of invasion***	Cohesive	13 (15.5)	1.00^†	0.839–10.374	0.09
	Noncohesive	71 (84.5)	2.95
Differentiation***	Well	45 (44.1)	1.00^†	0.258–1.009	0.05
	Moderate and poor	57 (55.9)	0.51

CI: confidence interval.
*Buccal mucosa, gingiva, lip, floor of mouth, palate.
^†Reference category.
**Multivariate logistic regression analysis was applied to adjust the confounders [age, gender, risk habits (cigarette smoking, betel quid chewing and alcohol drinking)] and clinico-parameters [tumor subsites, lymph node metastasis, tumor staging, pattern of invasion and pathological tumor differentiation].
***Data missing.