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The Scientific World Journal
Volume 2014, Article ID 902748, 5 pages
http://dx.doi.org/10.1155/2014/902748
Research Article

Oxidative Status and Acute Phase Reactants in Patients with Environmental Asbestos Exposure and Mesothelioma

1Department of Pulmonary Diseases, School of Medicine , Dicle University, 21280 Diyarbakir, Turkey
2Department of Biochemistry, School of Medicine, Dicle University, 21280 Diyarbakir, Turkey

Received 28 August 2013; Accepted 19 November 2013; Published 23 January 2014

Academic Editors: E. Hopper-Borge, N. Sunaga, and J. Thrasher

Copyright © 2014 Cengizhan Sezgi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and Objectives. The aim of this study was to investigate inflammatory indicators and oxidative status in patients with asbestos exposure with and without mesothelioma and to compare results with data from healthy subjects. Methods. Eighty people with exposure to environmental asbestos and without any disease, 46 mesothelioma patients, and a control group of 50 people without exposure to environmental asbestos were enrolled in this prospective study. Serum total oxidant level (TOL), total antioxidant capacity (TAC), and oxidative stress index (OSI), CRP, transferrin, ceruloplasmin, α-1 antitrypsin, ferritin, and copper levels were measured. Results. Mesothelioma group exhibited higher TOL, OSI, α1-antitrypsin, ferritin and copper levels as compared to the other groups (, , , , and , resp.). Transferrin was lower in the mesothelioma group than in the other two groups (). The asbestos group had higher TOL, TAC, α1-antitrypsin, and transferrin levels (, , , and , resp.), as well as lower OSI and ferritin levels as compared to the control group ( and ). Conclusions. We believe that elevated acute phase reactants and oxidative stress markers (TOL and OSI) in the mesothelioma group can be used as predictive markers for the development of asbestos-related malignancy.