Research Article

Suppression Effects of Betaine-Enriched Spinach on Hyperhomocysteinemia Induced by Guanidinoacetic Acid and Choline Deficiency in Rats

Table 1

Body weight gain, food intake, and liver weight of rats fed the experimental diets (experiments 1 and 2)1.

DietBody weight gain 
g/10 d
Food intake 
g/10 d
Liver weight 
g/100 g body weight

Experiment  1
 25C42.8 ± 1.6126 ± 54.49 ± 0.04a
 25CG46.2 ± 2.3125 ± 34.28 ± 0.07ab
 25CG + 0.05% Bet44.5 ± 2.2127 ± 64.28 ± 0.07ab
 25CG + 2.76% Spi50.4 ± 2.5122 ± 34.25 ± 0.05ab
 25CG + 0.10% Bet43.2 ± 2.2122 ± 34.21 ± 0.04b
 25CG + 5.52% Spi49.6 ± 1.8125 ± 44.17 ± 0.04b
 25CG + 0.20% Bet48.8 ± 2.3128 ± 34.27 ± 0.06ab
 25CG + 11.1% Spi50.2 ± 1.5122 ± 14.33 ± 0.05ab
Experiment  2
 25S40.5 ± 1.5136 ± 44.17 ± 0.05ab
 25SCD40.0 ± 1.8140 ± 34.30 ± 0.05a
 25SCD + 0.05% Bet44.0 ± 3.0142 ± 34.23 ± 0.04ab
 25SCD + 1.91% Spi46.9 ± 1.8143 ± 24.27 ± 0.06ab
 25SCD + 0.10% Bet43.3 ± 3.5135 ± 54.05 ± 0.05b
 25SCD + 3.82% Spi48.4 ± 2.0138 ± 44.08 ± 0.08ab

1Each value is the mean ± SEM, . Values with different letters are significantly different at . 25C, 25% casein diet; 25CG, 25C + 0.5% guanidinoacetic acid; 25S, 25% soybean protein diet; 25SCD, choline-deprived 25S; Bet, betaine; Spi, spinach.