Effects of Obstructive Sleep Apnea on Cardiac Function and Clinical Outcomes in Chinese Patients with ST-Elevation Myocardial Infarction

Table 4

Results of multivariate Cox regression analysis with MACE and cardiac death.

Characteristics	MACE		Cardiac death
	Hazard ratio (95% CI)	𝑃 value	Hazard ratio (95% CI)	𝑃 value
Gender	1.124 (0.538–2.351)	0.756	1.125 (0.283–4.477)	0.868
Old age (≥65 years)	0.871 (0.409–1.853)	0.720	1.382 (0.394–4.846)	0.613
Hypertension	1.310 (0.605–2.837)	0.493	0.675 (0.184–2.477)	0.553
Diabetes mellitus	3.088 (1.495–6.378)	0.002	9.057 (2.079–39.454)	0.003
Lipid disorders	2.279 (0.932–5.572)	0.071	1.395 (0.127–15.373)	0.786
CKD	1.010 (0.267–3.818)	0.988	0.252 (0.015–4.303)	0.341
Tobacco use	1.421 (0.526–3.839)	0.488	1.630 (0.403–6.596)	0.493
Drinking habit	0.779 (0.235–2.582)	0.682	0.253 (0.036–1.776)	0.167
OSA	3.946 (1.631–9.544)	0.002	11.189 (1.562–80.177)	0.016
Prior PCI	6.036 (0.636–57.273)	0.117	0.100 (1.130–1.150)	0.995
Prior CABG	1.970 (0.372–10.437)	0.425	0.100 (1.132–1.187)	0.986
LVEF	0.433 (0.962–11.017)	0.853	0.967 (0.929–1.007)	0.105
𝐸/𝑒^′ ratio	0.865 (0.719–1.041)	0.125	0.966 (0.675–1.381)	0.848
cTnT	0.999 (0.907–1.102)	0.991	1.189 (0.971–1.457)	0.094
WMA	1.231 (0.523–2.898)	0.634	2.294 (0.355–14.832)	0.383
DAPT adherence	0.126 (0.048–0.333)	<0.001	0.025 (0.004–0.160)	<0.001
Abdominal circumference	1.015 (0.974–1.058)	0.471	0.987 (0.914–1.066)	0.745
Socioeconomic status	1.647 (0.931–2.913)	0.086	1.118 (0.389–3.211)	0.835
BMI	0.940 (0.848–1.042)	0.239	0.933 (0.744–1.170)	0.547

CKD: chronic kidney disease; OSA: obstructive sleep apnea; PCI: percutaneous coronary intervention; CABG: coronary artery bypass grafting; LVEF: left ventricular ejection fraction; cTnT: cardiac troponin T; WMA: wall motion abnormality; DAPT: dual antiplatelet therapy; BMI: body mass index.