Caenorhabditis elegans as Model System in Pharmacology and Toxicology: Effects of Flavonoids on Redox-Sensitive Signalling Pathways and Ageing

Table 3

Influence of flavonoids and flavonoid-rich extracts on lipofuscin levels in C. elegans.

Compound	Treatment/incubation time		Lipofuscin; reduction (%)	References
Flavonoid: EGCG	220 μM	16 days; (starting one day after hatching)	39	Abbas and Wink, 2010 [69]
Fisetin	100 μM	4th day of adulthood; (starting from L4) (7 days old)	No difference	Kampkötter et al., 2007 [70]
Kaempferol	100 μM	4th day of adulthood; (starting from L4) (7 days old)	25	Kampkötter et al., 2007 [70]
Myricetin	100 μM	4th day of adulthood; (starting from L4) (7 days old)	33	Büchter et al., 2013 [38]
Quercetin	100 μM	7th day of adulthood (3 days)	40	Surco-Laos et al., 2012 [42]
	200 μM	4th day of adulthood; (starting from L1) (7 days old)	16	Pietsch et al., 2011 [35]
Flavonoid rich extract: blueberry polyphenols	200 μg/mL	Day 16; (starting from the first day of adulthood)	20	Wilson et al., 2006 [45]