Caenorhabditis elegans as Model System in Pharmacology and Toxicology: Effects of Flavonoids on Redox-Sensitive Signalling Pathways and Ageing

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">C. elegans gene</td><td align="left">Mammalian homologue</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">age-1</td><td align="left">Phosphatidylinositol 3-kinase</td></tr><tr><td align="left">akt-1, akt-2 </td><td align="left">Serine/threonine kinase Akt/PKB</td></tr><tr><td align="left">daf-12</td><td align="left">Nuclear receptor FXR</td></tr><tr><td align="left">daf-16</td><td align="left">FOXO transcription factor</td></tr><tr><td align="left">daf-2</td><td align="left">Insulin receptor, IGF-IR, IRR</td></tr><tr><td align="left">hsf-1 </td><td align="left">Heat shock factor 1</td></tr><tr><td align="left">ins-1 bis 37</td><td align="left">Insulin like peptide, IGF-I, IGF-II</td></tr><tr><td align="left">pdk-1 </td><td align="left">3-Phosphoinositide-dependent kinase 1</td></tr><tr><td align="left">skn-1 </td><td align="left">Nrf-2 transcription factor</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>Age: AGEing alteration; akt: AKT kinase family, daf: abnormal DAuer formation; FXR: farnesoid X receptor; FOXO: forkhead box O; IGF: insulin-like growth factor; Nrf: nuclear factor erythroid 2-related factor 2; skn: SKiNhead; ins: INSulin related. </td></tr></table>

Regulatory ageing-associated genes in C. elegans and their mammalian homologues.

The Scientific World Journal

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Table 4: Caenorhabditis elegans as Model System in Pharmacology and Toxicology: Effects of Flavonoids on Redox-Sensitive Signalling Pathways and Ageing

Table 4 | Caenorhabditis elegans as Model System in Pharmacology and Toxicology: Effects of Flavonoids on Redox-Sensitive Signalling Pathways and Ageing 