Caenorhabditis elegans as Model System in Pharmacology and Toxicology: Effects of Flavonoids on Redox-Sensitive Signalling Pathways and Ageing

Table 5

Modulation of gene expression and protein localisation of DAF-16 and its target SOD-3.

Effect	Flavonoid	Reference
Increased daf-16 mRNA expression	Aspalathin	Chen et al., 2013 [62]
Nuclear translocation of DAF-16	Apigenin	Kawasaki et al., 2010 [81]
	EGCG	Abbas and Wink, 2010 [69]
		Bartholome et al., 2010 [43]
	Fisetin	Kampkötter et al., 2007 [70]
	Kaempferol	Kampkötter et al., 2007 [70]
	Myricetin	Grünz et al., 2012 [36]
		Büchter et al., 2013 [38]
	Naringenin	Grünz et al., 2012 [36]
	Quercetin	Kampkötter et al., 2007 [37]
		Kampkötter et al., 2008 [30]
		Grünz et al., 2012 [36]
Increased sod-3 mRNA	Apigenin	Kawasaki et al., 2010 [81]
	Aspalathin	Chen et al., 2013 [62]
	EGCG	Zhang et al., 2009 [71]
Increased SOD-3 protein level	EGCG	Zhang et al., 2009 [71]
	Fisetin	Grünz et al., 2012 [36]
	Kaempferol	Grünz et al., 2012 [36]
	Myricetin	Grünz et al., 2012 [36]