Safety Evaluation of Multiple Strains of Lactobacillus plantarum and Pediococcus pentosaceus in Wistar Rats Based on the Ames Test and a 28-Day Feeding Study

Table 4

Organ relative weights in rats that were treated orally with multiple LAB Strains for 28 days.

Organ (%)		Control	Multiplex LAB strains
			Normal dose	High dose
Heart	M	0.32 ± 0.04^a	0.3 ± 0.03^a	0.31 ± 0.03^a
	F	0.31 ± 0.03^a	0.32 ± 0.02^a	0.34 ± 0.03^a
Liver	M	3.63 ± 0.3^b	3.28 ± 0.21^a	3.36 ± 0.23^a
	F	3.23 ± 0.22^a	3.27 ± 0.36^a	3.26 ± 0.21^a
Kidney (L)	M	0.37 ± 0.04^a	0.36 ± 0.02^a	0.36 ± 0.02^a
	F	0.37 ± 0.03^a	0.35 ± 0.03^a	0.32 ± 0.07^a
Kidney (R)	M	0.36 ± 0.03^a	0.34 ± 0.01^a	0.35 ± 0.02^a
	F	0.36 ± 0.02^a	0.34 ± 0.02^a	0.35 ± 0.01^a
Spleen	M	0.26 ± 0.02^b	0.22 ± 0.05^a	0.22 ± 0.03^a
	F	0.22 ± 0.02^a	0.25 ± 0.03^a	0.23 ± 0.02^a
Testicle (L)	M	0.43 ± 0.04^a	0.43 ± 0.05^a	0.43 ± 0.05^a
Testicle (R)	M	0.44 ± 0.04^a	0.44 ± 0.04^a	0.43 ± 0.05^a
Ovary (L)	F	0.09 ± 0.02^a	0.14 ± 0.05^a	0.08 ± 0.03^a
Ovary (R)	F	0.08 ± 0.02^a	0.14 ± 0.06^a	0.09 ± 0.02^a

All values are represented as the mean ± S.D. of Wistar rats ( = 8–10/sex/dose).
M: male; F: female.
^a,b compared with the control group by ANOVA followed by Duncan’s test.
Relative weight = (organ weight/body weight) × 100%.