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The Scientific World Journal
Volume 2014, Article ID 931845, 7 pages
http://dx.doi.org/10.1155/2014/931845
Research Article

High Association between Human Circulating MicroRNA-497 and Acute Myocardial Infarction

1Department of Cardiology, Guangzhou First Municipal People’s Hospital, Guangzhou Medical University, Panfu Road 1, Guangzhou, Guangdong 510180, China
2Southern Medical University, Guangzhou Avenue North 1838, Guangzhou, Guangdong 510515, China

Received 18 March 2014; Accepted 19 June 2014; Published 7 July 2014

Academic Editor: Lin He

Copyright © 2014 Zhenci Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recent papers have reported the fundamental roles of miR-497 in infarction which acute myocardial infarction (AMI) belongs to. However, the expression levels of miR-497 in AMI patients were unclear, especially the circulating miR-497 that was detectable in the human plasma. In this study, we focused on the expression levels of circulating miR-497 in AMI and the roles of plasma miR-497 as a promising biomarker for AMI. The plasma miR-497 levels were detected from 27 AMI patients and 31 healthy volunteers by qRT-PCR. The cTnI concentrations of these samples were also analyzed by ELISA. Results showed circulating miR-497 levels were upregulated in AMI patients at 4 h, 8 h, 12 h, and 24 h, by contrast to those in control. Interestingly, time courses of circulating miR-497 levels displayed similar trends to that of cTnI concentrations in AMI patients; further study revealed the high correlation between circulating miR-497 and cTnI concentrations ( , ). At last, the receiver operating characteristic (ROC) curve was performed and declared that there was a faithworthy sensitivity and specificity to identify the AMI patients by using circulating miR-497. In conclusion, circulating miR-497 might be a promising biomarker for AMI identification and there was high association between human miR-497 and acute myocardial infarction.