The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss?

Table 1

Effects of P2X7 receptors in immune cells.

Cell type	Cellular effect	Reference
Monocyte/macrophage	Activation of the inflammasome	[24, 25]
	Secretion of cytokines: IL1b, IL18, and TNF-𝛼	[26–28]
	Modulation of phagocytosis	[29]
	Macrophage death	[30]
	Promotion of multinucleated macrophages	[31, 32]
	Cathepsin release	[33]
	Enhance NO production and NOS2 expression	[34]
Dendritic cells	Maturation	[35]
	Apoptosis	[36, 37]
	Inflammasome activation	[38]
	Secretion of proinflammatory cytokines (IL1b, IL18, and TNF-𝛼).	[38]
Lymphocytes	Apoptosis	[35, 39]
	Proliferation	[40, 41]