Review Article
The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss?
Table 1
Effects of P2X7 receptors in immune cells.
| Cell type | Cellular effect | Reference |
| Monocyte/macrophage | Activation of the inflammasome | [24, 25] | Secretion of cytokines: IL1b, IL18, and TNF- | [26ā28] | Modulation of phagocytosis | [29] | Macrophage death | [30] | Promotion of multinucleated macrophages | [31, 32] | Cathepsin release | [33] | Enhance NO production and NOS2 expression | [34] |
| Dendritic cells | Maturation | [35] | Apoptosis | [36, 37] | Inflammasome activation | [38] | Secretion of proinflammatory cytokines (IL1b, IL18, and TNF-). | [38] | Lymphocytes | Apoptosis | [35, 39] | Proliferation | [40, 41] |
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