The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss?

Table 2

Published effects of P2X7 receptors in immune cells.

Cell type	Cellular effect	Reference
Osteoblast	RANKL expression (high ATP levels)	[42]
	Cell growth and bone formation though c-fos, ERK, PI3K, and COX	[43–47]
	Apoptosis	[48]
	Bone formation, membrane blebbing	[47, 49]
	Mineralization of bone matrix	[50]
	Mechanotransduction/mediate anabolic response to mechanical stimulation of bone	[51]
	Mediate ERK1/2 via fluid shear stress	[44]
	ATP release	[42, 52, 53]
	Fluid shear stress-induced NF-κB translocation	[54]
	Processing and secretion of cytokines	[55]
Osteoclast	Apoptosis/survival	[56, 57]
	Intercellular calcium signalling	[58]
	ATP release	[59]
	Precursor cell fusion and osteoclast cell fusion	[57, 60]
	Activation of NFκ β	[61, 62]