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The Scientific World Journal
Volume 2014, Article ID 964380, 5 pages
http://dx.doi.org/10.1155/2014/964380
Research Article

Effects of Paliperidone Palmitate on Coagulation: An Experimental Study

1Department of Psychiatry, Faculty of Medicine, Bezmialem University, Istanbul, Turkey
2Department of Biochemistry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey
3Department of Physiology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey
4Department of Pharmacology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey
5Department of Psychiatry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey
6Department of Pharmacology, Faculty of Medicine, Mevlana University, Konya, Turkey

Received 24 September 2013; Accepted 8 December 2013; Published 9 February 2014

Academic Editors: J. Csernansky and E. Ruther

Copyright © 2014 Enver Demirel Yılmaz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The aim of the present study was to examine the effects of a new antipsychotic drug paliperidone palmitate on hemogram and coagulation parameters in rats. Materials and Methods. Experiments were performed on 22 female albino Wistar rats (8–12 weeks old). Control group was given drinking water as vehicle (0.3 mL). PAL-1 rats were given 1 mg/kg paliperidone palmitate (in 0.3 mL drinking water) by oral gavage once a day for ten days and PAL-3 rats received 3 mg/kg paliperidone palmitate (in 0.3 mL drinking water) by oral gavage for ten days. Blood samples were drawn from the heart 24 hours after the last drug dose, and hemogram and coagulation parameters were measured with automated analyzers. Results. Hemogram did not change in the paliperidone treated groups compared to the controls. Factor VIII levels decreased in the PAL-1 and PAL-3 groups; and this decrease was significantly greater in the PAL-3. Factor IX levels decreased in PAL-3 rats, but its levels also increased in PAL-1 rats compared to the control. Discussion. Paliperidone has led to changes in the serum levels of coagulation factors VIII and IX in rats. As a result, paliperidone may be causing thromboembolism or bleeding in a dose-independent manner.