Effects of Paliperidone Palmitate on Coagulation: An Experimental Study

Table 2

Hemostatic parameters in control, PAL-1, and PAL-3 groups.

	Control (𝑛=8)	PAL-1 (𝑛=7)	PAL-3 (𝑛=7)
PT (sec)	12.30±0.40	12.58±0.43	12.14±0.44
INR (%)	0.98±0.03	1.00±0.03	0.96±0.04
aPTT (sec)	14.22±0.73	14.32±0.74	14.54±0.54
Fibrinogen (mg/dL)	212±115	254±217	178±44
Factor II (U/L)	74±6	74±4	74±6
Factor VIII (U/L)	283±47	70±23^∗	29±7^∗#
Factor IX (U/L)	86±8	105±15^∗	28±5^∗#
Factor X (U/L)	63±9	56±7	63±5
AT-III (%)	170±36	137±41	160±36
Protein C (μg/mL)	1.26±0.95	1.84±1.19	1.07±0.89
Protein S (μg/mL)	23.25±1.58	22.42±0.53	23.42±0.97

PAL-1 group: receiving paliperidone 1 mg/kg for ten days; PAL-3 group: receiving paliperidone 3 mg/kg for ten days. Values are expressed as means ± SD.
^∗𝑃<0.05 versus control group; ^#𝑃<0.05 versus PAL-1 group.