High-Dose Amoxicillin with Clavulanate for the Treatment of Acute Otitis Media in Children

Table 3

Factors relevant to poor outcome of acute otitis media (𝑛=165) by multivariate analysis (binary logistic regression model).

Variables	𝑃 value	OR of failed control (95% CI)
Girls	0.21	1.61 (0.77–3.36)
Weight*	0.48	0.98 (0.93–1.04)
Autumn/winter	0.02**	2.47 (1.17–5.23)
Bilateral AOM	0.09	1.96 (0.91–4.19)
Underdose	0.58	1.45 (0.38–5.53)

Abbreviations: AOM: acute otitis media; OR: odds ratio; CI: confidence interval. Reference groups in model: boys, illnesses in spring/summer, single-sided AOM, or high dose. ∗Age showed high collinearity with body weight in the model. Since antibiotics were given mainly based on body weight, weight was chosen instead of age in the regression model. ^∗∗𝑃<0.05.