Estrogen-Responsive Genes Overlap with Triiodothyronine-Responsive Genes in a Breast Carcinoma Cell Line

Table 1

Genes significantly modulated by E₂ and T₃ in MCF-7 cells.

Symbol	Gene	Biological process	Fold change; (adj. 𝑃 value)
			E2	T3
AREG	Amphiregulin, colorectum cell-derived, growth factor	Epidermal growth factor	18.13	3.63
FAD104	Fibronectin type III domain containing 3B	Positive regulation of fat cell differentiation	3.89	2.04
FBLN1	Fibulin 1	Interspecies interaction between organisms	2.60	2.53
POF1B	Premature ovarian failure, 1B	Protein encoded by this gene binds nonmuscle actin filaments	2.58	2.34
CLDN6	Claudin 6	Calcium-independent cell-cell adhesion	2.53	2.36
PCM1	Pericentriolar material 1	G2/M transition of mitotic cell cycle/microtubule anchoring	2.38	2,02
FLJ20073	Sterile alpha motif domain containing 9	Regulation of cell proliferation and apoptosis	2.22	2.46
VMP1	Likely ortholog of rat vacuole membrane protein 1	Cell-cell adhesion	2.41	2.11

Fold: expression difference; 𝑃 value: significance value of Student’s 𝑡-test; FDR: false discovery rate.