Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2014 (2014), Article ID 970363, 6 pages
http://dx.doi.org/10.1155/2014/970363
Research Article

The Effects of Trimetazidine and Sildenafil on Bilateral Cavernosal Nerve Injury Induced Oxidative Damage and Cavernosal Fibrosis in Rats

1Department of Urology, Medical Faculty, Gaziosmanpasa University, 60100 Tokat, Turkey
2Department of Pathology, Medical Faculty, Gaziosmanpasa University, 60100 Tokat, Turkey
3Department of Biochemistry, Medical Faculty, Gaziosmanpasa University, 60100 Tokat, Turkey
4Department of Biostatistics, Medical Faculty, Gaziosmanpasa University, 60100 Tokat, Turkey

Received 3 January 2014; Accepted 6 March 2014; Published 18 March 2014

Academic Editors: K. M. Azadzoi and A. Komiya

Copyright © 2014 Dogan Atilgan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. C. Walsh and P. J. Donker, “Impotence following radical prostatectomy: insight into etiology and prevention,” Journal of Urology, vol. 128, no. 3, pp. 492–497, 1982. View at Google Scholar · View at Scopus
  2. P. C. Walsh, P. Marschke, D. Ricker, and A. L. Burnett, “Patient-reported urinary continence and sexual function after anatomic radical prostatectomy,” Urology, vol. 55, no. 1, pp. 58–61, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Audouin, S. Beley, F. Cour et al., “Erectile dysfunction after radical prostatectomy: pathophysiology, evaluation and treatment,” Progres en Urologie, vol. 20, no. 3, pp. 172–182, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. C. D. Zippe, A. W. Kedia, K. Kedia, D. R. Nelson, and A. Agarwal, “Treatment of erectile dysfunction after radical prostatectomy with sildenafil citrate (Viagra),” Urology, vol. 52, no. 6, pp. 963–966, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. C. D. Zippe, F. M. Jhaveri, E. A. Klein et al., “Role of Viagra after radical prostatectomy,” Urology, vol. 55, no. 2, pp. 241–245, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. B. H. Lowentritt, P. T. Scardino, B. J. Miles et al., “Sildenafil citrate after radical retropubic prostatectomy,” Journal of Urology, vol. 162, no. 5, pp. 1614–1617, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. G. P. Zagaja, D. A. Mhoon, J. E. Aikens, and C. B. Brendler, “Sildenafil in the treatment of erectile dysfunction after radical prostatectomy,” Urology, vol. 56, no. 4, pp. 631–634, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. S. C. Sikka, “Relative impact of oxidative stress on male reproductive function,” Current Medicinal Chemistry, vol. 8, no. 7, pp. 851–862, 2001. View at Google Scholar · View at Scopus
  9. C. Migdal and M. Serres, “Reactive oxygen species and oxidative stress,” Medecine/Sciences, vol. 27, no. 4, pp. 405–412, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Singh and K. Chopra, “Effect of trimetazidine on renal ischemia/reperfusion injury in rats,” Pharmacological Research, vol. 50, pp. 623–629, 2004. View at Google Scholar
  11. V. Yukselen, A. O. Karaoglu, C. Yenisey, M. Tuncyurek, and O. Ozutemiz, “Trimetazidine reduces the degree of fibrosis in alkali burns of the esophagus,” Journal of Pediatric Surgery, vol. 40, no. 3, pp. 505–509, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. I. Iskesen, O. Saribulbul, M. Cerrahoglu, A. Var, Y. Nazli, and H. Sirin, “Trimetazidine reduces oxidative stress in cardiac surgery,” Circulation Journal, vol. 70, no. 9, pp. 1169–1173, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Baltalarli, E. Coskun, R. Ortac, G. Onem, I. Goksin, and B. H. Sirin, “Protective effects of trimetazidine in transient spinal cord ischemia,” Research in Experimental Medicine, vol. 200, pp. 43–51, 2000. View at Google Scholar
  14. S. Mohand-Said, A. Jacquet, A. Lucien, M. A. Espinasse-Berrod, M. Frasson Correa de Silva, and J. Sahel, “Protective effect of trimetazidine in a model of ischemia-reperfusion in the rat retina,” Ophthalmic Research, vol. 34, no. 5, pp. 300–305, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Unal, O. F. Karatas, M. Savas et al., “Protective effects of trimetazidine on testicular ischemia-reperfusion injury in rats,” Urologia Internationalis, vol. 78, no. 4, pp. 356–362, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Serarslan, R. Bal, M. E. Altug et al., “Effects of trimetazidine on crush injury of the sciatic nerve in rats: a biochemical and stereological study,” Brain Research, vol. 1247, pp. 11–20, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Sun, L. W. Oberley, and Y. Li, “A simple method for clinical assay of superoxide dismutase,” Clinical Chemistry, vol. 34, no. 3, pp. 497–500, 1988. View at Google Scholar · View at Scopus
  18. H. Esterbaur and K. H. Cheeseman, “Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hyroxynonenal,” in Methods in Enzymology, V. 186, Oxygen Radicals in Biological Systems, L. Packer and A. N. Glazer, Eds., pp. 407–421, Academic Press, New York, NY, USA, 1990. View at Google Scholar
  19. R. L. Levine, D. Garland, C. N. Oliver, A. Amici, I. Climent, and A. G. Lenz, “Determination of carbonyl content in oxidatively modified proteins,” in Methods in Enzymology, V. 186, Oxygen Radicals in Biological Systems, L. Packer and A. N. Glazer, Eds., pp. 464–478, Academic Press, New York, NY, USA, 1990. View at Google Scholar
  20. R. C. Dean and T. F. Lue, “Neuroregenerative strategies after radical prostatectomy,” Reviews in Urology, vol. 7, supplement 2, pp. S26–S32, 2005. View at Google Scholar
  21. M. G. Ferrini, I. Kovanecz, S. Sanchez, C. Umeh, J. Rajfer, and N. F. Gonzalez-Cadavid, “Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat,” Journal of Sexual Medicine, vol. 6, no. 2, pp. 415–428, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. L. T. Klein, M. I. Miller, R. Buttyan et al., “Apoptosis in the rat penis after penile denervation,” Journal of Urology, vol. 158, no. 2, pp. 626–630, 1997. View at Publisher · View at Google Scholar · View at Scopus
  23. H. M. User, J. H. Hairston, D. J. Zelner, K. E. McKenna, and K. T. McVary, “Penile weight and cell subtype specific changes in a postradical prostatectomy model of erectile dysfunction,” Journal of Urology, vol. 169, no. 3, pp. 1175–1179, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. R. B. Moreland, A. Traish, M. A. McMillin, B. Smith, I. Goldstein, and I. Saenz de Tejada, “PGE1 suppresses the induction of collagen synthesis by transforming growth factor-β1 in human corpus cavernosum smooth muscle,” Journal of Urology, vol. 153, no. 3, pp. 826–834, 1995. View at Publisher · View at Google Scholar · View at Scopus
  25. J. T. Daley, M. T. Watkins, M. L. Brown, V. Martinez, P. Cuevas, and I. Saenz de Tejada, “Prostanoid production in rabbit corpus cavernosum. II. Inhibition by oxidative stress,” Journal of Urology, vol. 156, no. 3, pp. 1169–1173, 1996. View at Google Scholar · View at Scopus
  26. R. B. Moreland, “Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the Society for the Study of Impotence,” International Journal of Impotence Research, vol. 10, no. 2, pp. 113–120, 1998. View at Google Scholar · View at Scopus
  27. C. Fischer, J. Gross, and J. Zuch, “Cycle of penile erection synchronous with dreaming (REM) sleep: preliminary report,” Archives of General Psychiatry, vol. 12, pp. 29–45, 1965. View at Google Scholar · View at Scopus
  28. S. Leungwattanakij, T. J. Bivalacqua, M. F. Usta et al., “Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum,” Journal of Andrology, vol. 24, no. 2, pp. 239–245, 2003. View at Google Scholar · View at Scopus
  29. D. M. Quinlan, J. I. Epstein, B. S. Carter, and P. C. Walsh, “Sexual function following radical prostatectomy: influence of preservation of neurovascular bundles,” Journal of Urology, vol. 145, no. 5, pp. 998–1002, 1991. View at Google Scholar · View at Scopus
  30. F. Montorsi, G. Guazzoni, L. F. Strambi et al., “Recovery of spontaneous erectile function after nervesparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: results of a prospective, randomized trial,” Journal of Urology, vol. 158, no. 4, pp. 1408–1410, 1997. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Montorsi, A. Briganti, A. Salonia, P. Rigatti, and A. L. Burnett, “Current and future strategies for preventing and managing erectile dysfunction following radical prostatectomy,” European Urology, vol. 45, no. 2, pp. 123–133, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. E. J. Schwartz, P. Wong, and R. J. Graydon, “Sildenafil preserves intracorporeal smooth muscle after radical retropubic prostatectomy,” Journal of Urology, vol. 171, no. 2, pp. 771–774, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. F. Montorsi and A. McCullough, “Efficacy of sildenafil citrate in men with erectile dysfunction following radical prostatectomy: a systematic review of clinical data,” Journal of Sexual Medicine, vol. 2, no. 5, pp. 658–667, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. M. G. Ferrini, H. H. Davila, I. Kovanecz, S. P. Sanchez, N. F. Gonzalez-Cadavid, and J. Rajfer, “Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the rat,” Urology, vol. 68, no. 2, pp. 429–435, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. H. Kim, D. W. Sohn, S. D. Kim et al., “The effect of mirodenafil on the penile erection and corpus cavernosum in the rat model of cavernosal nerve injury,” International Journal of Impotence Research, vol. 22, no. 5, pp. 291–297, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. E. Cadirci, Z. Halici, F. Odabasoglu et al., “Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study,” Clinical and Experimental Immunology, vol. 166, no. 3, pp. 374–384, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. H. Yildiz, A. S. Durmuş, H. Şimşek, and İ. Yaman, “Effects of sildenafil citrate on torsion/detorsion-induced changes in red blood cell and plasma lipid peroxidation, antioxidants, and blood hematology of male rats,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 159, no. 2, pp. 359–363, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. D. C. Guzmán, H. J. Olguín, N. O. Brizuela et al., “Effect of prostaglandin E1 (PGE1) and sildenafil on serotonin metabolism and some oxidative damage markers in rat prostate gland and brain,” Andrologia, vol. 43, no. 4, pp. 266–272, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. T. Hauet, G. Bauza, J. M. Goujon et al., “Effects of trimetazidine on lipid peroxidation and phosphorus metabolites during cold storage and reperfusion of isolated perfused rat kidneys,” Journal of Pharmacology and Experimental Therapeutics, vol. 285, no. 3, pp. 1061–1067, 1998. View at Google Scholar · View at Scopus
  40. I. Maridonneau-Parini and C. Harpey, “Effect of trimetazidine on membrane damage induced by oxygen free radicals in human red cells,” British Journal of Clinical Pharmacology, vol. 20, no. 2, pp. 148–151, 1985. View at Google Scholar · View at Scopus
  41. A. Elimadi, A. Settaf, D. Morin et al., “Trimetazidine counteracts the hepatic injury associated with ischemia- reperfusion by preserving mitochondrial function,” Journal of Pharmacology and Experimental Therapeutics, vol. 286, no. 1, pp. 23–28, 1998. View at Google Scholar · View at Scopus