Gossypol Promotes Degeneration of Ovarian Follicles in Rats

Table 1

Body weight, body weight gain (in grams), and length (in hours) of the estrous cycle phases of female rats dosed with gossypol (25 mg/kg/day) or 0.9% saline (control group) subcutaneously for 15 consecutive days.

	Control (𝑛=12)	Gossypol (𝑛=12)	𝑃 value^1
Body weight (g)
Day 0	190.4±4.32	192.2±7.62	n.s.
Day 15	197.5±2.91	186.7±6.15	n.s.
Body weight gain (g)	7.08±2.07	−5.58±2.43	0.0006792
Diestrus (h)	44.0±1.71	51.0±2.15	0.01875
Metestrus (h)	1.00±0.67	3.50±1.73	n.s.
Estrus (h)	24.5±1.88	20.0±1.71	n.s.
Proestrus (h)	26.5±1.16	21.5±2.39	n.s.

1Welch’s 𝑡 test.
n.s.: not significant (𝑃>0.05).