Iodine-131 Metaiodobenzylguanidine Therapy for Neuroblastoma: Reports So Far and Future Perspective

Figure 1

A 13-year-old female with relapsed neuroblastoma. She received the first I-131 MIBG therapy at a dose of 5.0 mCi/kg. Multiple accumulations are seen in a right retroperitoneal recurrence and multiple bone metastases ((a), arrows). The second I-131 MIBG therapy at a dose of 4.9 mCi/kg was performed 4 months after the first therapy. A scintigram after the second therapy shows a disappearance of left femoral uptake and decreasing uptakes in other lesions especially in a right retroperitoneum recurrence and a left humeral bone metastasis (b). Though the objective response at the first therapy was stable by the response evaluation criteria in solid tumors, she became free of pain in the lower extremity after the first therapy. Unfortunately, she died of progressive disease 14 months after the first I-131 MIBG therapy.

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