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The Scientific World Journal
Volume 2015, Article ID 235895, 5 pages
http://dx.doi.org/10.1155/2015/235895
Clinical Study

Association between Single Nucleotide Polymorphism of Vitamin D Receptor Gene FokI Polymorphism and Clinical Progress of Benign Prostatic Hyperplasia

1Department of Urology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou 510220, China
2Department of Urology, Guizhou Provincial People’s Hospital, Guizhou 550002, China
3Guizhou Provincial Key Laboratory of Computational Nano-Material Science, Guizhou Normal College, Guiyang 550018, China
4Department of Pathology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou 510220, China
5Department of Urology, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou 510180, China

Received 21 July 2014; Revised 10 August 2014; Accepted 17 August 2014

Academic Editor: Zhenyu Jia

Copyright © 2015 Li Ruan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The aim of the study was to investigate the association between single nucleotide polymorphism (SNP) of vitamin D receptor (VDR) gene and clinical progress of benign prostatic hyperplasia (BPH) in Chinese men. Methods. The DNA was extracted from blood of 200 BPH patients with operation (progression group) and 200 patients without operation (control group), respectively. The genotypes of VDR gene FokI SNP represented by “F/f” were identified by PCR-restriction fragment length polymorphism. The odds ratio (OR) of having progression of BPH for having the genotype were calculated. Results. Our date indicated that the f alleles of the VDR gene FokI SNP associated with the progression of BPH (). Conclusion. For the first time, our study demonstrated that VDR gene FokI SNP may be associated with the risk of BPH progress.