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The Scientific World Journal
Volume 2015, Article ID 239815, 5 pages
http://dx.doi.org/10.1155/2015/239815
Research Article

Isolated Vitamin D Deficiency Is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid Autoimmunity

1Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey
2Department of Biochemistry, Diskapi Training and Research Hospital, 06330 Ankara, Turkey
3Department of Endocrinology and Metabolism, School of Medicine, Ankara University, 06230 Ankara, Turkey
4Translational Research Center, Diskapi Teaching and Research Hospital, 06330 Ankara, Turkey
5Department of Internal Medicine, School of Medicine (Kastamonu), Hacettepe University, 06330 Ankara, Turkey

Received 28 July 2014; Accepted 14 December 2014

Academic Editor: Yehuda Shoenfeld

Copyright © 2015 Muyesser Sayki Arslan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. T. Cantorna, Y. Zhu, M. Froicu, and A. Wittke, “Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system,” The American Journal of Clinical Nutrition, vol. 80, no. 6, pp. 1717S–1720S, 2004. View at Google Scholar · View at Scopus
  2. H. F. Deluca and M. T. Cantorna, “Vitamin D: its role and uses in immunology,” The FASEB Journal, vol. 15, no. 14, pp. 2579–2585, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. H. S. Li, P. Verginis, and G. Carayanniotis, “Maturation of dendritic cells by necrotic thyrocytes facilitates induction of experimental autoimmune thyroiditis,” Clinical and Experimental Immunology, vol. 144, no. 3, pp. 467–474, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. C. M. Veldman, M. T. Cantorna, and H. F. DeLuca, “Expression of 1,25-dihydroxyvitamin D3 receptor in the immune system,” Archives of Biochemistry and Biophysics, vol. 374, no. 2, pp. 334–338, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. T. A. Pappa, A. G. Vagenakis, and M. Alevizaki, “The nonthyroidal illness syndrome in the non-critically ill patient,” European Journal of Clinical Investigation, vol. 41, no. 2, pp. 212–220, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. T. van der Poll, J. A. Romijn, W. M. Wiersinga, and H. P. Sauerwein, “Tumor necrosis factor: a putative mediator of the sick euthyroid syndrome in man,” Journal of Clinical Endocrinology and Metabolism, vol. 71, no. 6, pp. 1567–1572, 1990. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. Y.-T. Kuo, C.-H. Kuo, K.-P. Lam et al., “Effects of vitamin D3 on expression of tumor necrosis factor-α and chemokines by monocytes,” Journal of Food Science, vol. 75, no. 6, pp. H200–H204, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. M. Kankova, W. Luini, M. Pedrazzoni et al., “Impairment of cytokine production in mice fed a vitamin D3-deficient diet,” Immunology, vol. 73, no. 4, pp. 466–471, 1991. View at Google Scholar · View at Scopus
  9. C. H. A. Gouveia, M. A. Christoffolete, C. R. Zaitune et al., “Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation,” Endocrinology, vol. 146, no. 1, pp. 195–200, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. A. L. Maia, B. W. Kim, S. A. Huang, J. W. Harney, and P. R. Larsen, “Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans,” Journal of Clinical Investigation, vol. 115, no. 9, pp. 2524–2533, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. R. P. Peeters, P. J. Wouters, E. Kaptein, H. van Toor, T. J. Visser, and G. van den Berghe, “Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients,” The Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 7, pp. 3202–3211, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. B. G. Shelley, T. Quasim, J. Kinsella, D. Talwar, and D. C. McMillan, “Low-serum 25-hydroxyvitamin D reflects severity of illness in critically ill patients,” Critical Care Medicine, vol. 40, no. 8, pp. 2530–2532, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. M. L. Melamed, E. D. Michos, W. Post, and B. Astor, “25-hydroxyvitamin D levels and the risk of mortality in the general population,” Archives of Internal Medicine, vol. 168, no. 15, pp. 1629–1637, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. K. Plikat, J. Langgartner, R. Buettner et al., “Frequency and outcome of patients with nonthyroidal illness syndrome in a medical intensive care unit,” Metabolism: Clinical and Experimental, vol. 56, no. 2, pp. 239–244, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. A. C. Ross, J. E. Manson, S. A. Abrams et al., “The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know,” Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 1, pp. 53–58, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. G. Tamer, S. Arik, I. Tamer, and D. Coksert, “Relative vitamin D insufficiency in Hashimoto's thyroiditis,” Thyroid, vol. 21, no. 8, pp. 891–896, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. S. Kivity, N. Agmon-Levin, M. Zisappl et al., “Vitamin D and autoimmune thyroid diseases,” Cellular and Molecular Immunology, vol. 8, no. 3, pp. 243–247, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. M. Štefanić, S. Papić, M. Suver, L. Glavaš-Obrovac, and I. Karner, “Association of vitamin D receptor gene 3′-variants with Hashimoto's thyroiditis in the Croatian population,” International Journal of Immunogenetics, vol. 35, no. 2, pp. 125–131, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. W. Y. Lin, L. Wan, C. H. Tsai, R. H. Chen, C. C. Lee, and F. J. Tsai, “Vitamin D receptor gene polymorphisms are associated with risk of Hashimoto's thyroiditis in Chinese patients in Taiwan,” Journal of Clinical Laboratory Analysis, vol. 20, no. 3, pp. 109–112, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. M. Feng, H. Li, S.-F. Chen, W.-F. Li, and F.-B. Zhang, “Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis,” Endocrine, vol. 43, no. 2, pp. 318–326, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus