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The Scientific World Journal
Volume 2015, Article ID 285919, 6 pages
Research Article

Clinical Outcomes in Men and Women following Total Knee Arthroplasty with a High-Flex Knee: No Clinical Effect of Gender

1Physicians’ Clinic of Iowa, 202 10th Street Southeast, No. 140, Cedar Rapids, IA 52403, USA
2Department of Bioengineering, University of Illinois at Chicago, 851 S. Morgan Street, Chicago, IL 60607, USA

Received 23 February 2015; Revised 11 August 2015; Accepted 24 August 2015

Academic Editor: Michael M. Petersen

Copyright © 2015 Jeffrey M. Nassif and William S. Pietrzak. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


While it is generally recognized that anatomical differences exist between the male and female knee, the literature generally refutes the clinical need for gender-specific total knee prostheses. It has been found that standard, unisex knees perform as well, or better, in women than men. Recently, high-flex knees have become available that mechanically accommodate increased flexion yet no studies have directly compared the outcomes of these devices in men and women to see if gender-based differences exist. We retrospectively compared the performance of the high-flex Vanguard knee (Biomet, Warsaw, IN) in 716 male and 1,069 female knees. Kaplan-Meier survivorship was 98.5% at 5.6–5.7 years for both genders. After 2 years, mean improvements in Knee Society Knee and Function scores for men and women (50.9 versus 46.3; 26.5 versus 23.1) and corresponding SF-12 Mental and Physical scores (0.2 versus 2.2; 13.7 versus 12.2) were similar with differences not clinically relevant. Postoperative motion gains as a function of preoperative motion level were virtually identical in men and women. This further confirms the suitability of unisex total knee prostheses for both men and women.