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The Scientific World Journal
Volume 2015, Article ID 289267, 15 pages
http://dx.doi.org/10.1155/2015/289267
Review Article

Implication of Fructans in Health: Immunomodulatory and Antioxidant Mechanisms

Centro de Investigación y de Estudios Avanzados del IPN, Unidad Irapuato, Km 9.6 Libramiento Norte Carretera Irapuato-León, 36821 Irapuato, GTO, Mexico

Received 23 October 2014; Revised 29 January 2015; Accepted 6 March 2015

Academic Editor: Aida Turrini

Copyright © 2015 Elena Franco-Robles and Mercedes G. López. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. G. Lopez, N. A. Mancilla-Margalli, and G. Mendoza-Diaz, “Molecular structures of fructans from Agave tequilana Weber var. azul,” Journal of Agricultural and Food Chemistry, vol. 51, no. 27, pp. 7835–7840, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. J. van Loo, P. Coussement, L. de Leenheer, H. Hoebregs, and G. Smits, “On the presence of inulin and oligofructose as natural ingredients in the western diet,” Critical Reviews in Food Science and Nutrition, vol. 35, no. 6, pp. 525–552, 1995. View at Publisher · View at Google Scholar · View at Scopus
  3. C. J. Pollock and A. J. Cairns, “Fructan metabolism in grasses and cereals,” Annual Review of Plant Physiology and Plant Molecular Biology, vol. 42, no. 1, pp. 77–101, 1991. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Kelly, “Inulin-type prebiotics—a review: part 1,” Alternative Medicine Review, vol. 13, no. 4, pp. 315–329, 2008. View at Google Scholar · View at Scopus
  5. N. A. Mancilla-Margalli and M. G. Lopez, “Water-soluble carbohydrates and fructan structure patterns from Agave and Dasylirion species,” Journal of Agricultural and Food Chemistry, vol. 54, no. 20, pp. 7832–7839, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. C.-C. Tsai, C.-R. Lin, H.-Y. Tsai et al., “The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via toll-like receptor-2 signaling,” The Journal of Biological Chemistry, vol. 288, no. 24, pp. 17689–17697, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Vogt, D. Meyer, G. Pullens et al., “Immunological properties of inulin-type fructans,” Critical Reviews in Food Science and Nutrition, vol. 55, no. 3, pp. 414–436, 2014. View at Publisher · View at Google Scholar
  8. Q. Xu, T. Yajima, W. Li, K. Saito, Y. Ohshima, and Y. Yoshikai, “Levan (β-2, 6-fructan), a major fraction of fermented soybean mucilage, displays immunostimulating properties via Toll-like receptor 4 signalling: induction of interleukin-12 production and suppression of T-helper type 2 response and immunoglobulin E production,” Clinical & Experimental Allergy, vol. 36, no. 1, pp. 94–101, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. W. van den Ende, D. Peshev, and L. de Gara, “Disease prevention by natural antioxidants and prebiotics acting as ROS scavengers in the gastrointestinal tract,” Trends in Food Science and Technology, vol. 22, no. 12, pp. 689–697, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. G. A. F. Hendry, “Evolutionary origins and natural functions of fructans—a climatological, biogeographic and mechanistic appraisal,” New Phytologist, vol. 123, no. 1, pp. 3–14, 1993. View at Google Scholar · View at Scopus
  11. A. Cardelle-Cobas, N. Corzo, A. Olano, C. Peláez, T. Requena, and M. Ávila, “Galactooligosaccharides derived from lactose and lactulose: influence of structure on Lactobacillus, Streptococcus and Bifidobacterium growth,” International Journal of Food Microbiology, vol. 149, no. 1, pp. 81–87, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Iniguez-Covarrubias, R. Díaz-Teres, R. Sanjuan-Duenas, J. Anzaldo-Hernández, and R. M. Rowell, “Utilization of by-products from the tequila industry. Part 2: potential value of Agave tequilana Weber azul leaves,” Bioresource Technology, vol. 77, no. 2, pp. 101–108, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. I. Vijn and S. Smeekens, “Fructan: more than a reserve carbohydrate?” Plant Physiology, vol. 120, no. 2, pp. 351–359, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Ritsema and S. Smeekens, “Fructans: beneficial for plants and humans,” Current Opinion in Plant Biology, vol. 6, no. 3, pp. 223–230, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Kaur and A. K. Gupta, “Applications of inulin and oligofructose in health and nutrition,” Journal of Biosciences, vol. 27, no. 7, pp. 703–714, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. N. J. Chatterton and P. A. Harrison, “Fructan oligomers in Poa ampla,” New Phytologist, vol. 136, no. 1, pp. 3–10, 1997. View at Publisher · View at Google Scholar · View at Scopus
  17. J.-Z. Wei, N. J. Chatterton, P. A. Harrison, R. R.-C. Wang, and S. R. Larson, “Characterization of fructan biosynthesis in big bluegrass (Poa secunda),” Journal of Plant Physiology, vol. 159, no. 7, pp. 705–715, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. D. P. Livingston, N. J. Chatterton, and P. A. Harrison, “Structure and quantity of fructan oligomers in oat (Avena spp.),” New Phytologist, vol. 123, no. 4, pp. 725–734, 1993. View at Publisher · View at Google Scholar
  19. I. M. Sims, C. J. Pollock, and R. Horgan, “Structural analysis of oligomeric fructans from excised leaves of Lolium temulentum,” Phytochemistry, vol. 31, no. 9, pp. 2989–2992, 1992. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Pavis, N. J. Chatterton, P. A. Harrison et al., “Structure of fructans in roots and leaf tissues of Lolium perenne,” New Phytologist, vol. 150, no. 1, pp. 83–95, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Shiomi, “Properties of fructosyltransferases involved in the synthesis of fructan in liliaceous plants,” Journal of Plant Physiology, vol. 134, no. 2, pp. 151–155, 1989. View at Publisher · View at Google Scholar
  22. I. G. Carabin and W. Gary Flamm, “Evaluation of safety of inulin and oligofructose as dietary fiber,” Regulatory Toxicology and Pharmacology, vol. 30, no. 3, pp. 268–282, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. M. B. Roberfroid, “Concepts in functional foods: the case of inulin and oligofructose,” Journal of Nutrition, vol. 129, no. 7, pp. 1398S–1401s, 1999. View at Google Scholar · View at Scopus
  24. M. B. Roberfroid, “Inulin-type fructans: functional food ingredients,” Journal of Nutrition, vol. 137, no. 11, supplement, pp. 2493S–2502S, 2007. View at Google Scholar · View at Scopus
  25. M. B. Roberfroid, “Prebiotics: preferential substrates for specific germs?” American Journal of Clinical Nutrition, vol. 73, no. 2, supplement, pp. 406S–409S, 2001. View at Google Scholar · View at Scopus
  26. M. E. Sanders, F. Guarner, R. Guerrant et al., “An update on the use and investigation of probiotics in health and disease,” Gut, vol. 62, no. 5, pp. 787–796, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Kolida and G. R. Gibson, “Prebiotic capacity of inulin-type fructans,” Journal of Nutrition, vol. 137, no. 11, supplement, pp. 2503S–2506S, 2007. View at Google Scholar · View at Scopus
  28. S. H. Al-Sheraji, A. Ismail, M. Y. Manap, S. Mustafa, R. M. Yusof, and F. A. Hassan, “Prebiotics as functional foods: a review,” Journal of Functional Foods, vol. 5, no. 4, pp. 1542–1553, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. G. R. Gibson, H. M. Probert, J. Van Loo, R. A. Rastall, and M. B. Roberfroid, “Dietary modulation of the human colonic microbiota: updating the concept of prebiotics,” Nutrition Research Reviews, vol. 17, no. 2, pp. 259–275, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. E. Menne, N. Guggenbuhl, and M. Roberfroid, “Fn-type chicory inulin hydrolysate has a prebiotic effect in humans,” Journal of Nutrition, vol. 130, no. 5, pp. 1197–1199, 2000. View at Google Scholar · View at Scopus
  31. Y. Bouhnik, B. Flourié, L. D'Agay-Abensour et al., “Administration of transgalacto-oligosaccharides increases fecal bifidobacteria and modifies colonic fermentation metabolism in healthy humans,” Journal of Nutrition, vol. 127, no. 3, pp. 444–448, 1997. View at Google Scholar · View at Scopus
  32. M. Ito, Y. Deguchi, K. Matsumoto, M. Kimura, N. Onodera, and T. Yajima, “Influence of galactooligosaccharides on the human fecal microflora,” Journal of Nutritional Science and Vitaminology, vol. 39, no. 6, pp. 635–640, 1993. View at Publisher · View at Google Scholar · View at Scopus
  33. P. D. Cani, R. Bibiloni, C. Knauf et al., “Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice,” Diabetes, vol. 57, no. 6, pp. 1470–1481, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. N. M. Delzenne, A. M. Neyrinck, and P. D. Cani, “Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome,” Microbial Cell Factories, vol. 10, supplement 1, article S10, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. F. Di Bartolomeo, J. B. Startek, and W. van den Ende, “Prebiotics to fight diseases: reality or fiction?” Phytotherapy Research, vol. 27, no. 10, pp. 1457–1473, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. J. Tarini and T. M. S. Wolever, “The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects,” Applied Physiology, Nutrition and Metabolism, vol. 35, no. 1, pp. 9–16, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. J. J. Rumessen, S. Bodé, O. Hamberg, and E. Gudmand-Høyer, “Fructans of Jerusalem artichokes: intestinal transport, absorption, fermentation, and influence on blood glucose, insulin, and C-peptide responses in healthy subjects,” American Journal of Clinical Nutrition, vol. 52, no. 4, pp. 675–681, 1990. View at Google Scholar · View at Scopus
  38. T. van de Wiele, N. Boon, S. Possemiers, H. Jacobs, and W. Verstraete, “Inulin-type fructans of longer degree of polymerization exert more pronounced in vitro prebiotic effects,” Journal of Applied Microbiology, vol. 102, no. 2, pp. 452–460, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. D. Dai, N. N. Nanthkumar, D. S. Newburg, and W. A. Walker, “Role of oligosaccharides and glycoconjugates in intestinal host defense,” Journal of Pediatric Gastroenterology and Nutrition, vol. 30, supplement 2, pp. S23–S33, 2000. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Ortega-González, F. Sánchez De Medina, C. Molina-Santiago et al., “Fructooligosacharides reduce Pseudomonas aeruginosa PAO1 pathogenicity through distinct mechanisms,” PLoS ONE, vol. 9, no. 1, Article ID e85772, 2014. View at Publisher · View at Google Scholar · View at Scopus
  41. J. E. Urías-Silvas, P. D. Cani, E. Delmée, A. Neyrinck, M. G. López, and N. M. Delzenne, “Physiological effects of dietary fructans extracted from Agave tequilana Gto. and Dasylirion spp,” British Journal of Nutrition, vol. 99, no. 2, pp. 254–261, 2008. View at Google Scholar · View at Scopus
  42. S. G. Sáyago-Ayerdi, R. Mateos, R. I. Ortiz-Basurto et al., “Effects of consuming diets containing Agave tequilana dietary fibre and jamaica calyces on body weight gain and redox status in hypercholesterolemic rats,” Food Chemistry, vol. 148, pp. 54–59, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. P. A. Santiago-García and M. G. López, “Agavins from Agave angustifolia and Agave potatorum affect food intake, body weight gain and satiety-related hormones (GLP-1 and ghrelin) in mice,” Food & Function, vol. 5, no. 12, pp. 3311–3319, 2014. View at Publisher · View at Google Scholar
  44. M. I. McBurney, P. J. Van Soest, and J. L. Jeraci, “Colonic carcinogenesis: the microbial feast or famine mechanism,” Nutrition and Cancer, vol. 10, no. 1-2, pp. 23–28, 1987. View at Publisher · View at Google Scholar · View at Scopus
  45. V. De Preter, T. Vanhoutte, G. Huys et al., “Effects of Lactobacillus casei Shirota, Bifidobacterium breve, and oligofructose-enriched inulin on colonic nitrogen-protein metabolism in healthy humans,” The American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 292, no. 1, pp. G358–G368, 2007. View at Publisher · View at Google Scholar · View at Scopus
  46. E. Gomez, K. M. Tuohy, G. R. Gibson, A. Klinder, and A. Costabile, “In vitro evaluation of the fermentation properties and potential prebiotic activity of Agave fructans,” Journal of Applied Microbiology, vol. 108, no. 6, pp. 2114–2121, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. H. D. Holscher, J. L. Doligale, L. L. Bauer et al., “Gastrointestinal tolerance and utilization of agave inulin by healthy adults,” Food & Function, vol. 5, no. 6, pp. 1142–1149, 2014. View at Publisher · View at Google Scholar · View at Scopus
  48. A. R. Lomax and P. C. Calder, “Prebiotics, immune function, infection and inflammation: a review of the evidence,” British Journal of Nutrition, vol. 101, no. 5, pp. 633–658, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. K. Yamashita, K. Kawai, and M. Itakura, “Effects of fructo-oligosaccharides on blood glucose and serum lipids in diabetic subjects,” Nutrition Research, vol. 4, no. 6, pp. 961–966, 1984. View at Publisher · View at Google Scholar · View at Scopus
  50. P. D. Cani, C. Knauf, M. A. Iglesias, D. J. Drucker, N. M. Delzenne, and R. Burcelin, “Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor,” Diabetes, vol. 55, no. 5, pp. 1484–1490, 2006. View at Publisher · View at Google Scholar · View at Scopus
  51. A. Everard, V. Lazarevic, M. Derrien et al., “Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice,” Diabetes, vol. 60, no. 11, pp. 2775–2786, 2011. View at Publisher · View at Google Scholar
  52. F. Brighenti, “Dietary fructans and serum triacylglycerols: a meta-analysis of randomized controlled trials,” Journal of Nutrition, vol. 137, no. 11, supplement, pp. 2552S–2556S, 2007. View at Google Scholar · View at Scopus
  53. C. Daubioul, N. Rousseau, R. Demeure et al., “Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese Zucker fa/fa rats,” Journal of Nutrition, vol. 132, no. 5, pp. 967–973, 2002. View at Google Scholar · View at Scopus
  54. R. A. Reimer and J. C. Russell, “Glucose tolerance, lipids, and GLP-1 secretion in JCR:LA-cp rats fed a high protein fiber diet,” Obesity, vol. 16, no. 1, pp. 40–46, 2008. View at Publisher · View at Google Scholar · View at Scopus
  55. E. Sakaguchi, C. Sakoda, and Y. Toramaru, “Caecal fermentation and energy accumulation in the rat fed on indigestible oligosaccharides,” British Journal of Nutrition, vol. 80, no. 5, pp. 469–476, 1998. View at Google Scholar · View at Scopus
  56. C. A. Daubioul, H. S. Taper, L. D. de Wispelaere, and N. M. Delzenne, “Dietary oligofructose lessens hepatic steatosis, but does not prevent hypertriglyceridemia in obese Zucker rats,” Journal of Nutrition, vol. 130, no. 5, pp. 1314–1319, 2000. View at Google Scholar · View at Scopus
  57. E. Delmée, P. D. Cani, G. Gual et al., “Relation between colonic proglucagon expression and metabolic response to oligofructose in high fat diet-fed mice,” Life Sciences, vol. 79, no. 10, pp. 1007–1013, 2006. View at Publisher · View at Google Scholar · View at Scopus
  58. J. A. Jamieson, N. R. Ryz, C. G. Taylor, and H. A. Weiler, “Dietary long-chain inulin reduces abdominal fat but has no effect on bone density in growing female rats,” British Journal of Nutrition, vol. 100, no. 2, pp. 451–459, 2008. View at Google Scholar · View at Scopus
  59. P. D. Cani, S. Possemiers, T. van de Wiele et al., “Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability,” Gut, vol. 58, no. 8, pp. 1091–1103, 2009. View at Publisher · View at Google Scholar · View at Scopus
  60. B. Kleessen, S. Schwarz, A. Boehm et al., “Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers,” British Journal of Nutrition, vol. 98, no. 3, pp. 540–549, 2007. View at Publisher · View at Google Scholar · View at Scopus
  61. S. Wang, H. Zhu, C. Lu et al., “Fermented milk supplemented with probiotics and prebiotics can effectively alter the intestinal microbiota and immunity of host animals,” Journal of Dairy Science, vol. 95, no. 9, pp. 4813–4822, 2012. View at Publisher · View at Google Scholar · View at Scopus
  62. H. Hidaka, Y. Tashiro, and T. Eida, “Proliferation of bifidobacteria by oligosaccharides and their useful effect on human health,” Bifidobacteria and Microflora, vol. 10, no. 1, pp. 65–79, 1991. View at Publisher · View at Google Scholar
  63. J. Li and I. H. Kim, “Effects of levan-type fructan supplementation on growth performance, digestibility, blood profile, fecal microbiota, and immune responses after lipopolysaccharide challenge in growing pigs,” Journal of Animal Science, vol. 91, no. 11, pp. 5336–5343, 2013. View at Publisher · View at Google Scholar · View at Scopus
  64. Z. Zduńczyk, J. Juśkiewicz, and I. Estrella, “Cecal parameters of rats fed diets containing grapefruit polyphenols and inulin as single supplements or in a combination,” Nutrition, vol. 22, no. 9, pp. 898–904, 2006. View at Publisher · View at Google Scholar · View at Scopus
  65. J. Busserolles, E. Gueux, E. Rock, C. Demigné, A. Mazur, and Y. Rayssiguier, “Oligofructose protects against the hypertriglyceridemic and pro-oxidative effects of a high fructose diet in rats,” Journal of Nutrition, vol. 133, no. 6, pp. 1903–1908, 2003. View at Google Scholar · View at Scopus
  66. E. G. H. M. van den Heuvel, T. Muys, W. van Dokkum, and G. Schaafsma, “Oligofructose stimulates calcium absorption in adolescents,” The American Journal of Clinical Nutrition, vol. 69, no. 3, pp. 544–548, 1999. View at Google Scholar · View at Scopus
  67. H. Younes, C. Coudray, J. Bellanger, C. Demigné, Y. Rayssiguier, and C. Rémésy, “Effects of two fermentable carbohydrates (inulin and resistant starch) and their combination on calcium and magnesium balance in rats,” British Journal of Nutrition, vol. 86, no. 4, pp. 479–485, 2001. View at Publisher · View at Google Scholar · View at Scopus
  68. K. E. Scholz-Ahrens, P. Ade, B. Marten et al., “Prebiotics, probiotics, and synbiotics affect mineral absorption, bone mineral content, and bone structure,” Journal of Nutrition, vol. 137, no. 3, supplement 2, pp. 838S–846S, 2007. View at Google Scholar · View at Scopus
  69. M. I. García-Vieyra, A. del Real, and M. G. López, “Agave fructans: their effect on mineral absorption and bone mineral content,” Journal of Medicinal Food, vol. 17, no. 11, pp. 1247–1255, 2014. View at Publisher · View at Google Scholar
  70. P. Bodera, “Influence of prebiotics on the human immune system (GALT),” Recent Patents on Inflammation and Allergy Drug Discovery, vol. 2, no. 2, pp. 149–153, 2008. View at Publisher · View at Google Scholar · View at Scopus
  71. I. R. Sanderson, “Dietary modulation of GALT,” Journal of Nutrition, vol. 137, supplement 11, pp. 2557S–2562S, 2007. View at Google Scholar
  72. L. Mayer, “Mucosal immunity,” Pediatrics, vol. 111, no. 6, part 3, pp. 1595–1600, 2003. View at Google Scholar · View at Scopus
  73. T. T. MacDonald and G. Monteleone, “Immunity, inflammation, and allergy in the gut,” Science, vol. 307, no. 5717, pp. 1920–1925, 2005. View at Publisher · View at Google Scholar · View at Scopus
  74. A. M. Mowat, “Anatomical basis of tolerance and immunity to intestinal antigens,” Nature Reviews Immunology, vol. 3, no. 4, pp. 331–341, 2003. View at Publisher · View at Google Scholar · View at Scopus
  75. E. Ramiro-Puig, F. J. Pérez-Cano, C. Castellote, A. Franch, and M. Castell, “The bowel: a key component of the immune system,” Revista Espanola de Enfermedades Digestivas, vol. 100, no. 1, pp. 29–34, 2008. View at Google Scholar
  76. M. Rescigno, M. Urbano, B. Valzasina et al., “Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria,” Nature Immunology, vol. 2, no. 4, pp. 361–367, 2001. View at Publisher · View at Google Scholar · View at Scopus
  77. B. Jabri and E. Ebert, “Human CD8+ intraepithelial lymphocytes: a unique model to study the regulation of effector cytotoxic T lymphocytes in tissue,” Immunological Reviews, vol. 215, no. 1, pp. 202–214, 2007. View at Publisher · View at Google Scholar · View at Scopus
  78. J. H. Niess, S. Brand, X. Gu et al., “CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance,” Science, vol. 307, no. 5707, pp. 254–258, 2005. View at Publisher · View at Google Scholar · View at Scopus
  79. H. Cheroutre, “IELs: enforcing law and order in the court of the intestinal epithelium,” Immunological Reviews, vol. 206, no. 1, pp. 114–131, 2005. View at Publisher · View at Google Scholar · View at Scopus
  80. R. M. Steinman, “Decisions about dendritic cells: past, present, and future,” Annual Review of Immunology, vol. 30, no. 1, pp. 1–22, 2012. View at Publisher · View at Google Scholar
  81. J. Shiu and T. G. Blanchard, “Dendritic cell function in the host response to Helicobacter pylori infection of the gastric mucosa,” Pathogens and Disease, vol. 67, no. 1, pp. 46–53, 2013. View at Publisher · View at Google Scholar · View at Scopus
  82. J. L. Coombes and F. Powrie, “Dendritic cells in intestinal immune regulation,” Nature Reviews Immunology, vol. 8, no. 6, pp. 435–446, 2008. View at Publisher · View at Google Scholar
  83. C. M. Sun, J. A. Hall, R. B. Blank et al., “Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid,” Journal of Experimental Medicine, vol. 204, no. 8, pp. 1775–1785, 2007. View at Publisher · View at Google Scholar · View at Scopus
  84. S. Uematsu, K. Fujimoto, M. H. Jang et al., “Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5,” Nature Immunology, vol. 9, no. 7, pp. 769–776, 2008. View at Publisher · View at Google Scholar · View at Scopus
  85. T. L. Denning, B. A. Norris, O. Medina-Contreras et al., “Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization,” The Journal of Immunology, vol. 187, no. 2, pp. 733–747, 2011. View at Publisher · View at Google Scholar · View at Scopus
  86. O. Takeuchi and S. Akira, “Pattern recognition receptors and inflammation,” Cell, vol. 140, no. 6, pp. 805–820, 2010. View at Publisher · View at Google Scholar · View at Scopus
  87. M. Dalod, R. Chelbi, B. Malissen, and T. Lawrence, “Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming,” The EMBO Journal, vol. 33, no. 10, pp. 1104–1116, 2014. View at Publisher · View at Google Scholar · View at Scopus
  88. D. Han, M. C. Walsh, P. J. Cejas et al., “Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance,” Immunity, vol. 38, no. 6, pp. 1211–1222, 2013. View at Publisher · View at Google Scholar · View at Scopus
  89. X. Chen and J. J. Oppenheim, “Th17 cells and Tregs: unlikely allies,” Journal of Leukocyte Biology, vol. 95, no. 5, pp. 723–731, 2014. View at Publisher · View at Google Scholar · View at Scopus
  90. G. Reid, J. A. Younes, H. C. van der Mei, G. B. Gloor, R. Knight, and H. J. Busscher, “Microbiota restoration: natural and supplemented recovery of human microbial communities,” Nature Reviews Microbiology, vol. 9, no. 1, pp. 27–38, 2011. View at Publisher · View at Google Scholar · View at Scopus
  91. T. D. Leser and L. Mølbak, “Better living through microbial action: the benefits of the mammalian gastrointestinal microbiota on the host,” Environmental Microbiology, vol. 11, no. 9, pp. 2194–2206, 2009. View at Publisher · View at Google Scholar · View at Scopus
  92. S. K. Mazmanian, C. H. Liu, A. O. Tzianabos, and D. L. Kasper, “An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system,” Cell, vol. 122, no. 1, pp. 107–118, 2005. View at Publisher · View at Google Scholar · View at Scopus
  93. W. S. Garrett, J. I. Gordon, and L. H. Glimcher, “Homeostasis and inflammation in the intestine,” Cell, vol. 140, no. 6, pp. 859–870, 2010. View at Publisher · View at Google Scholar · View at Scopus
  94. I. I. Ivanov and K. Honda, “Intestinal commensal microbes as immune modulators,” Cell Host and Microbe, vol. 12, no. 4, pp. 496–508, 2012. View at Publisher · View at Google Scholar · View at Scopus
  95. S. K. Mazmanian, J. L. Round, and D. L. Kasper, “A microbial symbiosis factor prevents intestinal inflammatory disease,” Nature, vol. 453, no. 7195, pp. 620–625, 2008. View at Publisher · View at Google Scholar · View at Scopus
  96. B. Ruiz-Perez, D. R. Chung, A. H. Sharpe et al., “Modulation of surgical fibrosis by microbial zwitterionic polysaccharides,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 46, pp. 16753–16758, 2005. View at Publisher · View at Google Scholar · View at Scopus
  97. L. L. Presley, B. Wei, J. Braun, and J. Borneman, “Bacteria associated with immunoregulatory cells in mice,” Environmental Microbiology, vol. 76, no. 3, pp. 936–941, 2010. View at Publisher · View at Google Scholar
  98. K. Pokusaeva, G. F. Fitzgerald, and D. van Sinderen, “Carbohydrate metabolism in bifidobacteria,” Genes & Nutrition, vol. 6, no. 3, pp. 285–306, 2011. View at Publisher · View at Google Scholar · View at Scopus
  99. M. Blaut, “Relationship of prebiotics and food to intestinal microflora,” European Journal of Nutrition, vol. 41, no. 1, pp. 11–16, 2002. View at Google Scholar · View at Scopus
  100. A. Barcelo, J. Claustre, F. Moro, J.-A. Chayvialle, J.-C. Cuber, and P. Plaisancié, “Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon,” Gut, vol. 46, no. 2, pp. 218–224, 2000. View at Publisher · View at Google Scholar · View at Scopus
  101. A. J. Brown, S. M. Goldsworthy, A. A. Barnes et al., “The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids,” The Journal of Biological Chemistry, vol. 278, no. 13, pp. 11312–11319, 2003. View at Publisher · View at Google Scholar · View at Scopus
  102. E. Le Poul, C. Loison, S. Struyf et al., “Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation,” The Journal of Biological Chemistry, vol. 278, no. 28, pp. 25481–25489, 2003. View at Publisher · View at Google Scholar · View at Scopus
  103. N. E. Nilsson, K. Kotarsky, C. Owman, and B. Olde, “Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids,” Biochemical and Biophysical Research Communications, vol. 303, no. 4, pp. 1047–1052, 2003. View at Publisher · View at Google Scholar · View at Scopus
  104. D. K. Covington, C. A. Briscoe, A. J. Brown, and C. K. Jayawickreme, “The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing,” Biochemical Society Transactions, vol. 34, no. 5, pp. 770–773, 2006. View at Publisher · View at Google Scholar · View at Scopus
  105. K. M. Maslowski, A. T. Vieira, A. Ng et al., “Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43,” Nature, vol. 461, no. 7268, pp. 1282–1286, 2009. View at Publisher · View at Google Scholar · View at Scopus
  106. M. A. R. Vinolo, H. G. Rodrigues, E. Hatanaka, C. B. Hebeda, S. H. P. Farsky, and R. Curi, “Short-chain fatty acids stimulate the migration of neutrophils to inflammatory sites,” Clinical Science (Lond), vol. 117, no. 9, pp. 331–338, 2009. View at Publisher · View at Google Scholar · View at Scopus
  107. J.-S. Park, E.-J. Lee, J.-C. Lee, W.-K. Kim, and H.-S. Kim, “Anti-inflammatory effects of short chain fatty acids in IFN-γ-stimulated RAW 264.7 murine macrophage cells: involvement of NF-κB and ERK signaling pathways,” International Immunopharmacology, vol. 7, no. 1, pp. 70–77, 2007. View at Publisher · View at Google Scholar · View at Scopus
  108. M. A. R. Vinolo, H. G. Rodrigues, E. Hatanaka, F. T. Sato, S. C. Sampaio, and R. Curi, “Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils,” Journal of Nutritional Biochemistry, vol. 22, no. 9, pp. 849–855, 2011. View at Publisher · View at Google Scholar · View at Scopus
  109. D. J. A. Jenkins, C. W. C. Kendall, and V. Vuksan, “Inulin, oligofructose and intestinal function,” Journal of Nutrition, vol. 129, no. 7, pp. 1431S–1433S, 1999. View at Google Scholar · View at Scopus
  110. Y. Sanz, I. Nadal, and E. Sánchez, “Probiotics as drugs against human gastrointestinal infections,” Recent Patents on Anti-Infective Drug Discovery, vol. 2, no. 2, pp. 148–156, 2007. View at Publisher · View at Google Scholar · View at Scopus
  111. L. Vogt, U. Ramasamy, D. Meyer et al., “Immune modulation by different types of beta21-fructans is toll-like receptor dependent,” PLoS ONE, vol. 8, no. 7, Article ID e68367, 2013. View at Publisher · View at Google Scholar · View at Scopus
  112. L. M. Vogt, D. Meyer, G. Pullens et al., “Toll-like receptor 2 activation by β21-fructans protects barrier function of T84 human intestinal epithelial cells in a chain length-dependent manner,” Journal of Nutrition, vol. 144, no. 7, pp. 1002–1008, 2014. View at Publisher · View at Google Scholar
  113. N. R. Ryz, J. B. Meddings, and C. G. Taylor, “Long-chain inulin increases dendritic cells in the Peyer's patches and increases ex vivo cytokine secretion in the spleen and mesenteric lymph nodes of growing female rats, independent of zinc status,” British Journal of Nutrition, vol. 101, no. 11, pp. 1653–1663, 2009. View at Publisher · View at Google Scholar · View at Scopus
  114. J. Herre, S. Gordon, and G. D. Brown, “Dectin-1 and its role in the recognition of β-glucans by macrophages,” Molecular Immunology, vol. 40, no. 12, pp. 869–876, 2004. View at Publisher · View at Google Scholar · View at Scopus
  115. M. E. Taylor, J. T. Conary, M. R. Lennartz, P. D. Stahl, and K. Drickamer, “Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains,” The Journal of Biological Chemistry, vol. 265, no. 21, pp. 12156–12162, 1990. View at Google Scholar · View at Scopus
  116. A. C. Ouwehand, M. Derrien, W. de Vos, K. Tiihonen, and N. Rautonen, “Prebiotics and other microbial substrates for gut functionality,” Current Opinion in Biotechnology, vol. 16, no. 2, pp. 212–217, 2005. View at Publisher · View at Google Scholar · View at Scopus
  117. J. H. Cummings, G. T. Macfarlane, and H. N. Englyst, “Prebiotic digestion and fermentation,” The American Journal of Clinical Nutrition, vol. 73, no. 2, supplement, pp. 415S–420S, 2001. View at Google Scholar
  118. H. R. Gaskins, R. I. Mackie, T. May, and K. A. Garleb, “Dietary fructo-oligosaccharide modulates large intestinal inflammatory responses to Clostridium difficile in antibiotic-compromised mice,” Microbial Ecology in Health & Disease, vol. 9, no. 4, pp. 157–166, 1996. View at Publisher · View at Google Scholar
  119. C. J. Field, M. I. McBurney, S. Massimino, M. G. Hayek, and G. D. Sunvold, “The fermentable fiber content of the diet alters the function and composition of canine gut associated lymphoid tissue,” Veterinary Immunology and Immunopathology, vol. 72, no. 3-4, pp. 325–341, 1999. View at Publisher · View at Google Scholar · View at Scopus
  120. A. Letellier, S. Messier, L. Lessard, S. Chénier, and S. Quessy, “Host response to various treatments to reduce salmonella infections in swine,” Canadian Journal of Veterinary Research, vol. 65, no. 3, pp. 168–172, 2001. View at Google Scholar · View at Scopus
  121. R. Herich, V. Révajová, M. Levkut et al., “The effect of Lactobacillus paracasei and Raftilose P95 upon the non-specific immune response of piglets,” Food and Agricultural Immunology, vol. 14, pp. 171–179, 2002. View at Google Scholar
  122. K. S. Swanson, C. M. Grieshop, E. A. Flickinger et al., “Supplemental fructooligosaccharides and mannanoligosaccharides influence immune function, ileal and total tract nutrient digestibilities, microbial populations and concentrations of protein catabolites in the large bowel of dogs,” Journal of Nutrition, vol. 132, no. 5, pp. 980–989, 2002. View at Google Scholar · View at Scopus
  123. K. S. Swanson, C. M. Grieshop, E. A. Flickinger et al., “Effects of supplemental fructooligosaccharides plus mannanoligosaccharides on immune function and ileal and fecal microbial populations in adult dogs,” Archiv für Tierernährung, vol. 56, no. 4, pp. 309–318, 2002. View at Publisher · View at Google Scholar · View at Scopus
  124. H. Qiao, L. C. Duffy, E. Griffiths et al., “Immune responses in rhesus rotavirus-challenged Balb/c mice treated with bifidobacteria and prebiotic supplements,” Pediatric Research, vol. 51, no. 6, pp. 750–755, 2002. View at Publisher · View at Google Scholar · View at Scopus
  125. D. Bunout, S. Hirsch, M. P. de la Maza et al., “Effects of prebiotics on the immune response to vaccination in the elderly,” Journal of Parenteral and Enteral Nutrition, vol. 26, no. 6, pp. 372–376, 2002. View at Publisher · View at Google Scholar · View at Scopus
  126. Y. Guigoz, F. Rochat, G. Perruisseau-Carrier, I. Rochat, and E. J. Schiffrin, “Effects of oligosaccharide on the faecal flora and non-specific immune system in elderly people,” Nutrition Research, vol. 22, no. 1-2, pp. 13–25, 2002. View at Publisher · View at Google Scholar · View at Scopus
  127. A. Hosono, A. Ozawa, R. Kato et al., “Dietary fructooligosaccharides induce immunoregulation of intestinal IgA secretion by murine peyer's patch cells,” Bioscience, Biotechnology and Biochemistry, vol. 67, no. 4, pp. 758–764, 2003. View at Publisher · View at Google Scholar · View at Scopus
  128. K. A. Kelly-Quagliana, P. D. Nelson, and R. K. Buddington, “Dietary oligofructose and inulin modulate immune functions in mice,” Nutrition Research, vol. 23, no. 2, pp. 257–267, 2003. View at Publisher · View at Google Scholar · View at Scopus
  129. N. Manhart, A. Spittler, H. Bergmeister, M. Mittlböck, and E. Roth, “Influence of fructooligosaccharides on Peyer's patch lymphocyte numbers in healthy and endotoxemic mice,” Nutrition, vol. 19, no. 7-8, pp. 657–660, 2003. View at Publisher · View at Google Scholar · View at Scopus
  130. C. M. Grieshop, E. A. Flickinger, K. J. Bruce, A. R. Patil, G. L. Czarnecki-Maulden, and G. C. Fahey Jr., “Gastrointestinal and immunological responses of senior dogs to chicory and mannan-oligosaccharides,” Archives of Animal Nutrition, vol. 58, no. 6, pp. 483–493, 2004. View at Publisher · View at Google Scholar · View at Scopus
  131. Y. Nakamura, S. Nosaka, M. Suzuki et al., “Dietary fructooligosaccharides up-regulate immunoglobulin A response and polymeric immunoglobulin receptor expression in intestines of infant mice,” Clinical & Experimental Immunology, vol. 137, no. 1, pp. 52–58, 2004. View at Publisher · View at Google Scholar · View at Scopus
  132. M. Roller, G. Rechkemmer, and B. Watzl, “Prebiotic Inulin Enriched with Oligofructose in Combination with the Probiotics Lactobacillus rhamnosus and Bifidobacterium lactis modulates intestinal immune Functions in Rats,” Journal of Nutrition, vol. 134, no. 1, pp. 153–156, 2004. View at Google Scholar · View at Scopus
  133. D. Bunout, G. Barrera, S. Hirsch et al., “Effects of a nutritional supplement on the immune response and cytokine production in free-living Chilean elderly,” Journal of Parenteral and Enteral Nutrition, vol. 28, no. 5, pp. 348–354, 2004. View at Publisher · View at Google Scholar · View at Scopus
  134. B. Langkamp-Henken, B. S. Bender, E. M. Gardner et al., “Nutritional formula enhanced immune function and reduced days of symptoms of upper respiratory tract infection in seniors,” Journal of the American Geriatrics Society, vol. 52, no. 1, pp. 3–12, 2004. View at Publisher · View at Google Scholar · View at Scopus
  135. E. N. Trushina, E. A. Martynova, D. B. Nikityk, O. K. Mustafina, and E. K. Baygarin, “The influence of dietary inulin and oligofructose on the cell-mediated and humoral immunity in rats,” Voprosy Pitaniia, vol. 74, no. 3, pp. 22–27, 2005. View at Google Scholar · View at Scopus
  136. A. M. Bakker-Zierikzee, E. A. F. van Tol, H. Kroes, M. S. Alles, F. J. Kok, and J. G. Bindels, “Faecal SIgA secretion in infants fed on pre- or pro-biotic infant formula,” Pediatric Allergy and Immunology, vol. 17, no. 2, pp. 134–140, 2006. View at Publisher · View at Google Scholar · View at Scopus
  137. B. Langkamp-Henken, S. M. Wood, K. A. Herlinger-Garcia et al., “Nutritional formula improved immune profiles of seniors living in nursing homes,” Journal of the American Geriatrics Society, vol. 54, no. 12, pp. 1861–1870, 2006. View at Publisher · View at Google Scholar · View at Scopus
  138. V. Adogony, F. Respondek, V. Biourge et al., “Effects of dietary scFOS on immunoglobulins in colostrums and milk of bitches,” Journal of Animal Physiology and Animal Nutrition, vol. 91, no. 5-6, pp. 169–174, 2007. View at Publisher · View at Google Scholar · View at Scopus
  139. C. J. Apanavicius, K. L. Powell, B. M. Vester et al., “Fructan supplementation and infection affect food intake, fever, and epithelial sloughing from salmonella challenge in weanling puppies,” Journal of Nutrition, vol. 137, no. 8, pp. 1923–1930, 2007. View at Google Scholar · View at Scopus
  140. C. Seidel, V. Boehm, H. Vogelsang et al., “Influence of prebiotics and antioxidants in bread on the immune system, antioxidative status and antioxidative capacity in male smokers and non-smokers,” British Journal of Nutrition, vol. 97, no. 2, pp. 349–356, 2007. View at Publisher · View at Google Scholar · View at Scopus
  141. J. Benyacoub, F. Rochat, K.-Y. Saudan et al., “Feeding a diet containing a fructooligosaccharide mix can enhance Salmonella vaccine efficacy in mice,” Journal of Nutrition, vol. 138, no. 1, pp. 123–129, 2008. View at Google Scholar · View at Scopus
  142. P. A. M. J. Scholtens, P. Alliet, M. Raes et al., “Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides,” Journal of Nutrition, vol. 138, no. 6, pp. 1141–1147, 2008. View at Google Scholar · View at Scopus
  143. J. Vulevic, A. Drakoularakou, P. Yaqoob, G. Tzortzis, and G. R. Gibson, “Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers,” The American Journal of Clinical Nutrition, vol. 88, no. 5, pp. 1438–1446, 2008. View at Publisher · View at Google Scholar · View at Scopus
  144. E. van Hoffen, B. Ruiter, J. Faber et al., “A specific mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides induces a beneficial immunoglobulin profile in infants at high risk for allergy,” Allergy, vol. 64, no. 3, pp. 484–487, 2009. View at Publisher · View at Google Scholar · View at Scopus
  145. Y. Li, Y. Zong, J. Qi, and K. Liu, “Prebiotics and oxidative stress in constipated rats,” Journal of Pediatric Gastroenterology and Nutrition, vol. 53, no. 4, pp. 447–452, 2011. View at Publisher · View at Google Scholar · View at Scopus
  146. G. T. Choque Delgado, R. Thomé, D. L. Gabriel, W. M. S. C. Tamashiro, and G. M. Pastore, “Yacon (Smallanthus sonchifolius)-derived fructooligosaccharides improves the immune parameters in the mouse,” Nutrition Research, vol. 32, no. 11, pp. 884–892, 2012. View at Publisher · View at Google Scholar · View at Scopus
  147. J.-M. Lecerf, F. Dépeint, E. Clerc et al., “Xylo-oligosaccharide (XOS) in combination with inulin modulates both the intestinal environment and immune status in healthy subjects, while XOS alone only shows prebiotic properties,” British Journal of Nutrition, vol. 108, no. 10, pp. 1847–1858, 2012. View at Publisher · View at Google Scholar · View at Scopus
  148. J. Vulevic, A. Juric, G. Tzortzis, and G. R. Gibson, “A mixture of trans-galactooligosaccharides reduces markers of metabolic syndrome and modulates the fecal microbiota and immune function of overweight adults1-3,” The Journal of Nutrition, vol. 143, no. 3, pp. 324–331, 2013. View at Publisher · View at Google Scholar · View at Scopus
  149. G. Bouchaud, L. Castan, J. Chabauty, P. Aubert, M. Neunlist, and M. Bodinier, “11: perinatal exposure to galactooligosaccharides/inulin prebiotics prevent food allergy by protecting intestine and promoting tolerance,” Cytokine, vol. 70, no. 1, 30 pages, 2014. View at Publisher · View at Google Scholar
  150. C. E. Childs, H. Röytiö, E. Alhoniemi et al., “Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study,” British Journal of Nutrition, vol. 111, no. 11, pp. 1945–1956, 2014. View at Publisher · View at Google Scholar · View at Scopus
  151. L. Samal, V. B. Chaturvedi, G. Saikumar, R. Somvanshi, and A. K. Pattanaik, “Prebiotic potential of Jerusalem artichoke (Helianthus tuberosus L.) in Wistar rats: effects of levels of supplementation on hindgut fermentation, intestinal morphology, blood metabolites and immune response,” Journal of the Science of Food and Agriculture, 2014. View at Publisher · View at Google Scholar
  152. A. Huazano-García and M. G. López, “Metabolism of short chain fatty acids in colon and faeces of mice after a supplementation of diets with agave fructans,” in Lipid Metabolism, R. Valenzuela Baez, Ed., vol. 8, pp. 163–182, InTech, Rijeka, Croatia, 2013. View at Publisher · View at Google Scholar
  153. S. K. Chen, M. L. Tsai, J. R. Huang, and R. H. Chen, “In vitro antioxidant activities of low-molecular-weight polysaccharides with various functional groups,” Journal of Agricultural and Food Chemistry, vol. 57, no. 7, pp. 2699–2704, 2009. View at Publisher · View at Google Scholar · View at Scopus
  154. E. Hernandez-Marin and A. Martínez, “Carbohydrates and their free radical scavenging capability: a theoretical study,” Journal of Physical Chemistry B, vol. 116, no. 32, pp. 9668–9675, 2012. View at Publisher · View at Google Scholar · View at Scopus
  155. E. Keunen, D. Peshev, J. Vangronsveld, W. van den Ende, and A. Cuypers, “Plant sugars are crucial players in the oxidative challenge during abiotic stress: extending the traditional concept,” Plant, Cell and Environment, vol. 36, no. 7, pp. 1242–1255, 2013. View at Publisher · View at Google Scholar · View at Scopus
  156. W. Van den Ende and D. Peshev, “Sugars as antioxidants in plants,” in Crop Improvement Under Adverse Conditions, N. Tuteja and S. S. Gill, Eds., pp. 285–307, Springer, New York, NY, USA, 2013. View at Publisher · View at Google Scholar
  157. D. Peshev, R. Vergauwen, A. Moglia, É. Hideg, and W. Van den Ende, “Towards understanding vacuolar antioxidant mechanisms: a role for fructans?” Journal of Experimental Botany, vol. 64, no. 4, pp. 1025–1038, 2013. View at Publisher · View at Google Scholar · View at Scopus
  158. C. H. Foyer, M. Lelandais, and K. J. Kunert, “Photooxidative stress in plants,” Physiologia Plantarum, vol. 92, no. 4, pp. 696–717, 1994. View at Google Scholar · View at Scopus
  159. A. Nishizawa, Y. Yabuta, and S. Shigeoka, “Galactinol and raffinose constitute a novel function to protect plants from oxidative damage,” Plant Physiology, vol. 147, no. 3, pp. 1251–1263, 2008. View at Publisher · View at Google Scholar · View at Scopus
  160. S. Stoyanova, J. Geuns, É. Hideg, and W. Van den Ende, “The food additives inulin and stevioside counteract oxidative stress,” International Journal of Food Sciences and Nutrition, vol. 62, no. 3, pp. 207–214, 2011. View at Publisher · View at Google Scholar · View at Scopus
  161. X. M. Li, Y. H. Shi, F. Wang, H. S. Wang, and G. W. Le, “In vitro free radical scavenging activities and effect of synthetic oligosaccharides on antioxidant enzymes and lipid peroxidation in aged mice,” Journal of Pharmaceutical and Biomedical Analysis, vol. 43, no. 1, pp. 364–370, 2007. View at Publisher · View at Google Scholar · View at Scopus
  162. M. Glei, T. Hofmann, K. Küster, J. Hollmann, M. G. Lindhauer, and B. L. Pool-Zobel, “Both wheat (Triticum aestivum) bran arabinoxylans and gut flora-mediated fermentation products protect human colon cells from genotoxic activities of 4-hydroxynonenal and hydrogen peroxide,” Journal of Agricultural and Food Chemistry, vol. 54, no. 6, pp. 2088–2095, 2006. View at Publisher · View at Google Scholar · View at Scopus
  163. J. Juśkiewicz, Z. Zduńczyk, E. Zary-Sikorska, B. Król, J. Milala, and A. Jurgoński, “Effect of the dietary polyphenolic fraction of chicory root, peel, seed and leaf extracts on caecal fermentation and blood parameters in rats fed diets containing prebiotic fructans,” British Journal of Nutrition, vol. 105, no. 5, pp. 710–720, 2011. View at Publisher · View at Google Scholar · View at Scopus