Histologic and Metabolic Derangement in High-Fat, High-Fructose, and Combination Diet Animal Models

Table 1

Biochemical parameters according to nonalcoholic fatty liver disease model.

Parameter	Control	HF	HF + HFr combination	HFr
AST (U/L)	143 ± 25.5	336 ± 108.3	230.3 ± 78	240 ± 83.9	0.035
ALT (U/L)	44 ± 4.6	60.7 ± 22.4	48.9 ± 12.9	40.7 ± 8.7	0.049
T.bili (mg/dL)	0.02 ± 0.01	0.06 ± 0.03	0.03 ± 0.01	0.04 ± 0.02	0.121
IL-6 (pg/mL)	13.1 ± 6.1	10.3 ± 5	9.3 ± 7.9	11.3 ± 7.5	0.127
Insulin (pmol/L)	1,181 ± 1020.4	2,092.3 ± 1113.4	1,518.5 ± 1217.5	1,227.8 ± 364.2	0.513

AST: aspartate transaminase; ALT: alanine transaminase; T.bili: total bilirubin; IL-6: interleukin-6. by Kruskal-Wallis test.