Effect of In Vitro Transcorneal Approach of Aceclofenac Eye Drops through Excised Goat, Sheep, and Buffalo Corneas

Table 3

In vitro relative permeation characteristics of aceclofenac from control and optimized formulation through excised goat, sheep, and buffalo corneas.

Animal	Thickness of; cornea mm	Control formulation			Optimized formulation BAC; benzalkonium chloride
		Amount permeated (mg) (120 minutes)	Permeation (%) (120 minutes)	Papp cm/sec * 10^6	Amount permeated (mg) (120 minutes)	Permeation (%) (120 minutes)	Papp cm/sec * 10^6
Goat	0.68 ± 0.0003	2.8 ± 0.002	56	9.998 ± 0.86	4.4 0.004	84	15.01 ± 0.45
Sheep	0.86 ± 0.0003	1.2 ± 0.009	24	3.36 ± 0.12	2.8 0.008	76	9.60 ± 0.03
Buffalo	1.12 ± 0.0006	1.1 ± 0.004	22	2.99 ± 0.36	1.7 0.005	34	4.91 ± 0.21

Values are mean ± SE of three corneas in each group. Statistically significant ( < 0.05) determined by one-way ANOVA followed by Dunnett’s test.
Note: All the experiments were carried out in triplicates.