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The Scientific World Journal
Volume 2015, Article ID 458080, 6 pages
http://dx.doi.org/10.1155/2015/458080
Research Article

The Vasorelaxant Effect of p-Cymene in Rat Aorta Involves Potassium Channels

1Programa de Pós-Graduação em Recursos Naturais do Semiárido (PGRNSA), Universidade Federal do Vale do São Francisco (UNIVASF), Campus Centro, 56304-205 Petrolina, PE, Brazil
2Curso de Farmácia, Universidade Federal do Vale do São Francisco (UNIVASF), Campus Centro, 56304-205 Petrolina, PE, Brazil
3Centro de Ciências Biológicas e da Saúde, Departamento de Fisiologia, Universidade Federal de Sergipe, Campus de São Cristóvão, 49100-001 Aracaju, SE, Brazil
4Colegiado de Ciências Farmacêuticas (CFARM), Universidade Federal do Vale do São Francisco (UNIVASF), Campus Centro, 56304-205 Petrolina, PE, Brazil

Received 25 July 2014; Revised 15 December 2014; Accepted 29 December 2014

Academic Editor: Xavier Norel

Copyright © 2015 Martapolyana T. M. Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The monoterpenes are the main constituents of most essential oils and p-cymene is a monoterpene commonly found in various species of aromatic herbs, which has been reported for anti-inflammatory, antinociceptive, and antimicrobial activities. However, there is no report concerning its pharmacological activity on the vascular smooth muscle. The aim of current work was to investigate the effects of p-cymene in isolated rat aorta and also study its mechanism of action. In this work, we show that p-cymene has a relaxant effect, in a dose-dependent way, on the vascular smooth muscle, regardless of the presence of the endothelium. Using a nonselective potassium channel blocker, the CsCl, the relaxant effect of p-cymene was attenuated. In the presence of more selective potassium channels blockers, such as TEA or 4-AP, no change in the relaxant effect of p-cymene was evidenced, indicating that and channels are not involved in that relaxant effect. However, in the presence of glibenclamide or BaCl2, and blockers, respectively, the relaxant effect of p-cymene was attenuated. The data presented indicate that p-cymene has a relaxing effect on rat aorta, regardless of the endothelium, but with the participation of the and channels.