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The Scientific World Journal
Volume 2015, Article ID 495271, 7 pages
http://dx.doi.org/10.1155/2015/495271
Research Article

Formulation and Evaluation of Galantamine Gel as Drug Reservoir in Transdermal Patch Delivery System

1Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43300 Serdang, Selangor, Malaysia
2Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43300 Serdang, Selangor, Malaysia

Received 8 October 2014; Revised 15 January 2015; Accepted 4 February 2015

Academic Editor: Herbert Budka

Copyright © 2015 Woo Fong Yen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of Alzheimer’s disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal disturbance. Transdermal delivery of galantamine hydrobromide could avoid these unwanted side effects. In this work, galantamine hydrobromide was formulated in gel drug reservoir which was then fabricated in the transdermal patch. The in vitro drug release studies revealed that the drug release from the donor chamber to receptor chamber of Franz diffusion cell was affected by the amount of polymer, amount of neutralizer, amount of drug, types of permeation enhancer, and amount of permeation enhancer. Visual observations of the gels showed that all formulated gels are translucent, homogeneous, smooth, and stable. These gels have pH in the suitable range for skin. The gel also showed high drug content uniformity. Hence, this formulation can be further used in the preparation of transdermal patch drug delivery system.