Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery

Table 2

Composition of nanoemulsifying preconcentrate formulation using Box-Behnken design.

	Levels
Independent factors	Low		Middle		High
	Code	Actual (mg)	Code	Actual (mg)	Code	Actual (mg)
: Conc. of Peceol (mg)	−1	200	0	300	1	400
: Conc. of Cremophor EL (mg)	−1	300	0	400	1	450
: Conc. of Transcutol HP (mg)	−1	100	0	150	1	200
Constraints
Dependent variables			Goal
: Mean globule size (nm)			Minimize
: Emulsification time (min)			In range
: time required for drug release (85%); (min)			In range