Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery
Table 3
Combination levels of independent variables and the outcome of response variables by Box-Behnken design.
Batch No.
Independent factor
Expected response
Predicted response
P1
−1
−1
0
166.81
2.60
23.75
162.65
2.71
22.74
P2
+1
−1
0
176.83
2.00
21.36
183.63
1.94
20.71
P3
−1
+1
0
136.14
4.84
25.30
129.28
4.90
25.95
P4
+1
+1
0
157.72
4.56
24.58
161.85
4.45
25.59
P5
−1
0
−1
105.21
6.00
26.14
116.49
6.11
26.45
P6
+1
0
−1
169.50
4.65
25.14
169.81
4.93
25.09
P7
−1
0
+1
153.44
4.50
24.29
153.09
4.22
24.34
P8
+1
0
+1
164.62
4.31
23.63
153.31
4.20
23.32
P9
0
+1
+1
160.12
4.25
21.78
152.96
4.03
22.48
P10
0
+1
−1
147.60
6.12
26.49
143.14
5.95
25.53
P11
0
−1
+1
176.31
2.12
18.59
180.76
2.29
19.55
P12
0
−1
−1
128.30
4.86
25.29
135.44
5.08
24.59
P13
0
0
0
156.15
4.12
22.93
152.96
4.30
23.63
P14
0
0
0
145.90
4.21
23.95
152.96
4.30
23.63
P15
0
0
0
160.10
4.31
24.05
152.96
4.30
23.63
P16
0
0
0
158.81
4.85
24.81
152.96
4.30
23.63
P17
0
0
0
143.92
4.00
22.43
152.96
4.30
23.63
Standard deviation of observed responses found within ± 5%. Peceol (oil); Cremophor EL (polymer); Transcutol HP (adsorbent). Mean globule size (nm); Emulsification time (min); (min).
