Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery

Table 4

Evaluation parameters of optimized CUR-LNP and CUR-SNP.

(a) Optimized CUR-LNP

Code	Globule size		Drug Release	Viscosity (Poise)	Drug loading (%)
	-avg. (nm)	PDI	(min)
P3	136.1	0.498	25.30	4.98	70.13
P5	105.2	0.690	26.14	4.12	64.21
P12	128.3	0.323	25.29	5.57	61.86

(b) Optimized CUR-SNP

Code	-avg (nm)	PDI	(min)	Powder properties			Drug Loading (%)
				Carr’s Index (%)	Hausner’s ratio	Angle of Repose ()
SP	141.8	0.428	26.17	20.16	1.29	34.43	57.18
SP	153.3	0.510	28.89	18.64	1.18	32.64	75.30
SP	169.1	0.628	31.12	17.64	1.16	31.12	69.15

Nanoemulsion preconcentrate with LNP: Aerosil 200; 1 : 1, 1 : 5, 1 : 10 respectively.