Research Article
Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery
Table 4
Evaluation parameters of optimized CUR-LNP and CUR-SNP.
(a) Optimized CUR-LNP |
| Code | Globule size | Drug Release | Viscosity (Poise) | Drug loading (%) | -avg. (nm) | PDI | (min) |
| P3 | 136.1 | 0.498 | 25.30 | 4.98 | 70.13 | P5 | 105.2 | 0.690 | 26.14 | 4.12 | 64.21 | P12 | 128.3 | 0.323 | 25.29 | 5.57 | 61.86 |
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(b) Optimized CUR-SNP |
| Code | -avg (nm) | PDI | (min) | Powder properties | Drug Loading (%) | Carr’s Index (%) | Hausner’s ratio | Angle of Repose () |
| SP | 141.8 | 0.428 | 26.17 | 20.16 | 1.29 | 34.43 | 57.18 | SP | 153.3 | 0.510 | 28.89 | 18.64 | 1.18 | 32.64 | 75.30 | SP | 169.1 | 0.628 | 31.12 | 17.64 | 1.16 | 31.12 | 69.15 |
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Nanoemulsion preconcentrate with LNP: Aerosil 200; 1 : 1, 1 : 5, 1 : 10 respectively.
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