The Effects of Tempol on Cyclophosphamide-Induced Oxidative Stress in Rat Micturition Reflexes

Figure 4

Cyclophosphamide- (CYP-) induced cystitis increases adenosine triphosphate (ATP) in the urinary bladder and cystometric fluid and the antioxidant, Tempol, reduces expression. (a) 4 hr and 48 hr CYP-induced cystitis significantly () increased ATP expression in urinary bladder that was significantly () reduced with Tempol. Tempol was without effect on ATP expression in urinary bladder from control (no CYP) rats. (b) 4 hr and 48 hr CYP-induced cystitis significantly () increased ATP expression in cystometric fluid that was significantly () reduced with Tempol. Tempol was without effect on ATP expression in cystometric fluid from control (no CYP) rats. . for control and treatment groups.

(a)

(b)