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The Scientific World Journal
Volume 2015, Article ID 657932, 8 pages
http://dx.doi.org/10.1155/2015/657932
Research Article

Granulocyte-Colony Stimulating Factor Increases Cerebral Blood Flow via a NO Surge Mediated by Akt/eNOS Pathway to Reduce Ischemic Injury

1Department of Medical Research, Buddhist Tzu Chi General Hospital, No. 707, Section 3, Zhongyang Road, Hualien City 970, Taiwan
2Institute of Pharmacology and Toxicology, Tzu Chi University, No. 701, Section 3, Zhongyang Road, Hualien City 970, Taiwan
3Graduate Institute of Medical Sciences, Taipei Medical University, No. 250, Wu-Hsing Street, Taipei 110, Taiwan
4Institute of Medical Sciences, Tzu Chi University, No. 701, Section 3, Zhongyang Road, Hualien City 970, Taiwan

Received 20 June 2014; Revised 6 November 2014; Accepted 7 November 2014

Academic Editor: Robert M. Starke

Copyright © 2015 Hock-Kean Liew et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [5 citations]

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  • Hae In Lee, Sae-Won Lee, So Young Kim, Nam Gyun Kim, Kyoung-Jun Park, Byung Tae Choi, Yong-Il Shin, and Hwa Kyoung Shin, “Pretreatment with light-emitting diode therapy reduces ischemic brain injury in mice through endothelial nitric oxide synthase-dependent mechanisms,” Biochemical and Biophysical Research Communications, vol. 486, no. 4, pp. 945–950, 2017. View at Publisher · View at Google Scholar
  • Janet M. Menzie-Suderam, Payam Mohammad-Gharibani, Jigar Modi, Zea Ma, Rui Tao, Howard Prentice, and Jang-Yen Wu, “Granulocyte-Colony Stimulating Factor protects against Endoplasmic reticulum stress in an experimental model of stroke,” Brain Research, 2017. View at Publisher · View at Google Scholar
  • Mihael Mišir, Marija Renić, Sanja Novak, Martina Mihalj, Anita Ćosić, Monika Vesel, and Ines Drenjančević, “Hyperbaric oxygenation and 20-hydroxyeicosatetreanoic acid inhibition reduce stroke volume in female diabetic Sprague-Dawley rats,” Experimental Physiology, 2017. View at Publisher · View at Google Scholar
  • Rasha El-Esawy, Mohamed Balaha, Samah Kandeel, Sabeha Hadya, and Mohamed-Nabih Abd El-Rahman, “Filgrastim (G-CSF) ameliorates Parkinsonism l -dopa therapy’s drawbacks in mice,” Basal Ganglia, vol. 13, pp. 17–26, 2018. View at Publisher · View at Google Scholar
  • Beibei Dong, Zhishen Zhang, Keliang Xie, Yongyan Yang, Yuan Shi, Chenxu Wang, and Yonghao Yu, “Hemopexin promotes angiogenesis via up-regulating HO-1 in rats after cerebral ischemia-reperfusion injury,” BMC Anesthesiology, vol. 18, no. 1, 2018. View at Publisher · View at Google Scholar