The Scientific World Journal

Review Article

Radiotracers Used for the Scintigraphic Detection of Infection and Inflammation

Table 2

Commercial radiopharmaceuticals currently used in clinical nuclear medicine.


Product trade Name/code	Manufacturer/sponsor		Final dose preparation^a,b	Mode of administration	Indications^c
Product trade Name/code	Origin	Description	Final dose preparation^a,b	Mode of administration	Indications^c

CERETEC	UK	Kit for the preparation of technetium [^99mTc] exametazime injection	Simple	Intravenous	Scintigraphic localization of seizure foci in patients with temporal lobe epilepsy

LEUCOCYTE Labelling Kit [LLK]	Australia	Kit for the preparation of technetium [^99mTc] labelled leucocytes (^99mTc-Sn(O)F₂)	Complex	Intravenous	Image acute inflammation or infection

MDP	Many	Kit for the preparation of technetium [^99mTc] medronate injection	Simple	Intravenous	Skeletal imaging pharmaceutical

Indium [¹¹¹In] oxine	UK, Netherlands	A diagnostic radiopharmaceutical intended for radiolabelling	Simple	Intravenous	In vitro radiolabeling of separated leukocytes and platelets which are subsequently reinjected intravenously for investigative purposes

Gallium [⁶⁷Ga] citrate injection	Many	An injection containing radioactive gallium [⁶⁷Ga]	Simple	Intravenous	It may be useful in demonstrating the presence and extent of Hodgkin’s disease, lymphomas, and bronchogenic carcinoma and may also be useful as an aid in detecting some acute inflammatory lesions

Fluorodeoxyglucose [¹⁸F] injection	Many	A positron emitting radiopharmaceutical containing no-carrier added radioactive 2-deoxy-2-[¹⁸F]fluoro-D-glucose	Simple	Intravenous	Identification of regions of abnormal glucose metabolism associated with foci of epileptic seizures, in the evaluation of malignancy in patients and identification of left ventricular myocardium with residual glucose metabolism and reversible loss of systolic function

LeukoScan	USA, Germany	Kit for the preparation of ^99mTc-labeled LeukoScan	Simple	Intravenous	For determining the location and extent of infection/inflammation in bone in patients with suspected osteomyelitis, including patients with diabetic foot ulcers

Scintimun	France	Scintimun 1 mg kit for radiopharmaceutical preparation	Complex	Intravenous	For determining the location of inflammation/infection in peripheral bone in adults with suspected osteomyelitis

Nanocoll	Italy	Kit for radiopharmaceutical preparation (^99mTc-HAA)	Simple	Intravenous	Bone marrow scanning (excluding hematopoietic activity) and inflammation scanning (excluding the abdomen)

Simple operations involving one radioisotope reconstitution step/withdrawal of final patient dose(s); ^bcomplex operations involving multisteps of reconstitution/heating/other manipulations/purification/withdrawal of final patient dose(s); ^cfrom the Product Information Sheet.