Association between Polymorphism of Interleukin-1beta and Interleukin-1 Receptor Antagonist Gene and Asthma Risk: A Meta-Analysis

Table 3

Stratified analyses of the IL-1β-511C/T polymorphism on asthma risk in meta-analysis.

		Case/control	CC versus TT		TC versus TT		CC/TC versus TT		CC versus TC/CC
			OR (95% CI)		OR (95% CI)		OR (95% CI)		OR (95% CI)
Total	10	1385/1964	1.12 [0.96, 1.32]	0.15	1.10 [0.98, 1.21]	0.10	1.11 [0.91, 1.25]	0.06	1.10 [0.93, 1.31]	0.11
Ethnicities
Asian	5	748/1018	1.05 [0.78, 1.41]	0.77	1.02 [0.80, 1.29]	0.97	1.03 [0.82, 1.28]	0.96	1.03 [0.80, 1.33]	0.68
Caucasian	5	637/946	1.24 [0.88, 1.76]	0.11	1.19 [0.94, 1.52]	0.006^C	1.20 [0.95, 1.52]	0.01^C	1.06 [0.78, 1.44]	0.03^C
Source of control
PB	4	597/806	1.29 [0.90, 1.84]	0.81	1.14 [0.91, 1.43]	0.05	1.11 [0.86, 1.41]	0.05	1.04 [0.91, 1.20]	0.18
HB	6	788/1158	1.03 [0.77, 1.37]	0.81	1.07 [0.82, 1.38]	0.14	1.13 [0.91, 1.39]	0.26	0.95 [0.74, 1.22]	0.23
Mean of age
Adult	6	830/1277	1.03 [0.78, 1.35]	0.86	1.04 [0.85, 1.28]	0.03^C	1.05 [0.06, 1.27]	0.10	0.98 [0.77, 1.24]	0.24
Childhood	4	555/687	1.35 [0.90, 2.40]	0.05	1.24 [0.93, 1.66]	0.41	1.26 [0.95, 1.67]	0.30	1.24 [0.88, 1.75]	0.18

: number of comparisons.
: value of -test for heterogeneity test.
^CRandom effects model was used when value for heterogeneity test <0.05; otherwise, fixed effects model was used.