Association between Polymorphism of Interleukin-1beta and Interleukin-1 Receptor Antagonist Gene and Asthma Risk: A Meta-Analysis

Table 4

Stratified analyses of the IL-1RA polymorphism on asthma risk in meta-analysis.

		Case/control	AA versus GG		GA versus GG		AA/GA versus GG		AA versus GA/GG
			OR (95% CI)		OR (95% CI)		OR (95% CI)		OR (95% CI)
Total	10	2800/6359	1.32 [1.12, 1.56]	0.87	0.95 [0.88, 1.02]	0.001C	0.99 [0.92, 1.07]	0.01C	1.39 [1.18, 1.63]	0.82
Ethnicities
Asian	3	1224/1582	1.41 [0.64, 3.10]	0.15	1.32 [1.08, 1.60]	0.13	1.32 [1.09, 1.60]	0.27	1.33 [0.60, 2.91]	0.13
Caucasian	7	1576/4777	1.31 [1.03, 1.68]	0.87	0.81 [0.71, 0.93]	0.001^C	0.88 [0.78, 1.00]	0.001^C	1.39 [1.10, 1.77]	0.86
Source of control
PB	6	2284/5364	1.30 [1.02, 1.65]	0.88	1.02 [0.91, 1.15]	0.01^C	1.07 [0.95, 1.19]	0.11	1.35 [1.07, 1.70]	0.75
HB	4	516/995	2.02 [0.65, 6.32]	0.27	0.57 [0.41, 0.78]	0.0001^C	0.64 [0.45, 0.83]	0.0001^C	2.71 [0.83, 8.89]	0.36
Mean of age
Adult	6	2014/2836	1.05 [0.81, 1.36]	0.83	1.17 [1.03, 1.34]	0.02^C	1.16 [1.02, 1.32]	0.07	0.96 [0.76, 1.21]	0.22
Childhood	4	786/3523	1.45 [1.06, 1.97]	0.16	0.74 [0.37, 1.48]	0.0001^C	0.76 [0.39, 1.49]	0.0001^C	1.36 [1.01, 1.82]	0.75

: number of comparisons.
: value of -test for heterogeneity test.
^CRandom effects model was used when value for heterogeneity test <0.05; otherwise, fixed effects model was used.