Development of PET and SPECT Probes for Glutamate Receptors

Figure 2

Ex vivo autoradiograms of [¹²⁵I]CNS 1261 in the caudate nucleus (white arrow) and cerebral cortex (black arrow) of rat brain (a). Quantified regional isotope levels normalized to cerebellum (b). The animals were injected with [¹²⁵I]CNS 1261 15 min after permanent occlusion of the middle cerebral artery (left hemisphere) and sacrificed 120 min later [26].

(a)

(b)