Development of PET and SPECT Probes for Glutamate Receptors

Figure 6

In vitro autoradiogram of [¹¹C]7 (a) and quantified values of the autoradiogram in frontal cortex (FTX), hippocampus (HIP), striatum (STR), thalamus (THA), and cerebellum (CB) (b). Nonspecific binding was determined in the presence of (+) CP-101,606 (10 μM). (c) Time radioactivity curves in the monkey brain after administration of [¹¹C]7. Nonradioactive 7 (2 mg/kg) was coinjected with [¹¹C]7 into the same monkey [55].

(a)

(b)

(c)