Comment on “Evidence for Negative Effects of Elevated Intra-Abdominal Pressure on Pulmonary Mechanics and Oxidative Stress”

Figure 1

An impact of CO₂-pneumoperitoneum on respiratory, blood gases, and oxygen status parameters: (a) the end-tidal CO₂ concentration (CO₂) and ventilation rate (VR) parameters in 12 newborns, suffering laparoscopic surgical procedures due to ovarian tumors, at the time of induction (0), at the time of incision (1), and every 10 minutes during (2–9) and after (10) laparoscopic surgery with CO₂-pneumoperitoneum at 7–9 mmHg (eleven sampling points) from [2], unpublished data); (b) an arterial blood carbon dioxide partial pressure (pCO₂), pH, oxyhemoglobin (O₂Hb), and oxygen tension at half saturation assessing the hemoglobin oxygen affinity (p50): in rabbits without pneumoperitoneum (control), spontaneously breathing animals (series I), superficially ventilated animals (series II), and optimally ventilated animals with insufflation pressures of 10 mmHg (series IIIA) or 6 mmHg (series IIIB). Values are means ± SD (modified from [3]).

(a)

(b)