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The Scientific World Journal
Volume 2015, Article ID 787451, 10 pages
Research Article

The “Gender Factor” in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP Study

1Novartis Farma S.p.A., Origgio, Varese 21040, Italy
2Department of Neurosciences, University of Genoa, Genoa 16132, Italy
3Department of Parkinson’s Disease, IRCCS San Camillo, Venice 30126, Italy
4Scuola Medica Salernitana, Università degli Studi di Salerno, Salerno 84100, Italy
5Department of Biomedical Science, University of Sassari, Sassari 07100, Italy
6MediData srl, Modena 41123, Italy
7Department of Neurology, San Camillo-Forlanini Hospital, Rome 00151, Italy
8Department of Neurology, Institute of Research and Medical Care, IRCCS San Raffaele, Rome 00163, Italy

Received 11 October 2014; Revised 13 December 2014; Accepted 21 December 2014

Academic Editor: Lawrence W. Svenson

Copyright © 2015 Delia Colombo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The early detection of wearing-off in Parkinson disease (DEEP) observational study demonstrated that women with Parkinson’s disease (PD) carry an increased risk (80.1%) for wearing-off (WO). This post hoc analysis of DEEP study evaluates gender differences on WO and associated phenomena. Methods. Patients on dopaminergic treatment for ≥1 year were included in this multicenter observational cross-sectional study. In a single visit, WO was diagnosed based on neurologist assessment as well as the use of the 19-item wearing-off questionnaire (WOQ-19); WO was defined for scores ≥2. Post hoc analyses were conducted to investigate gender difference for demographic and clinical features with respect to WO. Results. Of 617 patients enrolled, 236 were women and 381 were men. Prevalence of WO was higher among women, according to both neurologists’ judgment (61.9% versus 53.8%, ) and the WOQ-19 analysis (72.5% versus 64.0%, ). In patients with WO (WOQ-19), women experienced ≥1 motor symptom in 72.5% versus 64.0% in men and ≥1 nonmotor symptom in 44.5% versus 36.7%, in men. Conclusions. Our results suggest WO as more common among women, for both motor and nonmotor symptoms. Prospective studies are warranted to investigate this potential gender-effect.