The “Gender Factor” in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP Study

Table 3

Frequency of experienced symptoms and WO symptoms, as reported by DEEP population, through the WOQ-19, stratified by disease duration: women versus men.

Disease duration	<5 years		>5 years		Total
	()		()		()
	Women; ()	Men; ()	Women; ()	Men; ()	Women; ()	Men; ()
Referred motor symptoms by WOQ-19, mean ± SD
Experienced	4.6 ± 2.2	4.8 ± 2.1	6.0 ± 1.9	5.9 ± 2.0	5.6 ± 2.1	5.5 ± 2.1
WO	2.0 ± 2.1	2.0 ± 2.4	3.8 ± 2.4	3.5 ± 2.6	3.3 ± 2.5	3.0 ± 2.6
Referred nonmotor symptoms by WOQ-19, mean ± SD
Experienced	2.9 ± 2.0	2.3 ± 2.2	4.0 ± 2.3	3.0 ± 2.2	3.7 ± 2.3	2.8 ± 2.2
WO	0.7 ± 1.3	0.5 ± 1.1	1.4 ± 1.9	1.1 ± 1.6	1.2 ± 1.8	0.9 ± 1.5
Experienced and WO symptoms, mean ± SD
Experienced	7.5 ± 3.6	7.1 ± 3.8	9.9 ± 3.6	8.9 ± 3.7	9.3 ± 3.8	8.3 ± 3.8
WO	2.7 ± 2.8	2.4 ± 3.1	5.2 ± 3.9	4.5 ± 3.8	4.5 ± 3.8	3.9 ± 3.7
Experienced and WO symptoms, (%)
Tremor
Experienced	48 (72.7)	81 (68.1)	117 (68.8)	180 (68.7)	165 (69.9)	261 (68.5)
WO	29 (43.9)	40 (33.6)	96 (56.5)	127 (48.5)	125 (53.0)	167 (43.8)
Difficulty in speech
Experienced	14 (21.2)	51 (42.9)	62 (36.5)	152 (58.0)	76 (32.2)	203 (53.3)
WO	8 (12.1)	21 (17.6)	28 (16.5)	76 (29.0)	36 (15.3)	97 (25.5)
Weakness
Experienced	48 (72.7)	72 (60.5)	129 (75.9)	184 (70.2)	177 (75.0)	256 (67.2)
WO	14 (21.2)	27 (22.7)	68 (40.0)	102 (38.9)	82 (34.7)	129 (33.9)
Problems with balance
Experienced	24 (36.4)	49 (41.2)	110 (64.7)	136 (51.9)	134 (56.8)	185 (48.6)
WO	7 (10.6)	18 (15.1)	48 (28.2)	64 (24.4)	55 (23.3)	82 (21.5)
Slowness of movements
Experienced	50 (75.8)	90 (75.6)	157 (92.4)	227 (86.6)	207 (87.7)	317 (83.2)
WO	27 (40.9)	42 (35.3)	122 (71.8)	153 (58.4)	149 (63.1)	195 (51.2)
Reduced dexterity
Experienced	36 (54.5)	85 (71.4)	143 (84.1)	219 (83.6)	179 (75.8)	317 (79.8)
WO	18 (27.3)	37 (31.1)	101 (59.4)	145 (55.3)	119 (50.4)	182 (47.8)
General stiffness
Experienced	22 (33.3)	49 (41.2)	98 (57.6)	168 (64.1)	120 (50.8)	217 (57.0)
WO	12 (18.2)	27 (22.7)	80 (47.1)	122 (46.6)	92 (39.0)	149 (39.1)
Muscle cramps
Experienced	36 (54.5)	57 (47.9)	100 (58.8)	138 (52.7)	136 (57.6)	195 (51.2)
WO	11 (16.7)	11 (9.2)	37 (21.8)	48 (18.3)	48 (20.3)	59 (15.5)
Difficulty getting out of chair
Experienced	24 (36.4)	36 (30.2)	98 (57.6)	137 (52.3)	122 (51.7)	173 (45.4)
WO	6 (9.1)	11 (9.2)	62 (36.5)	79 (30.1)	68 (28.8)	90 (23.6)
Anxiety
Experienced	42 (63.6)	49 (41.2)	112 (65.9)	123 (46.9)	154 (65.3)	172 (45.1)
WO	10 (15.1)	13 (10.9)	46 (27.1)	45 (17.2)	56 (23.7)	58 (15.2)
Sweating
Experienced	16 (24.2)	30 (25.2)	85 (50.0)	102 (38.9)	101 (42.8)	132 (34.6)
WO	3 (4.5)	4 (3.4)	19 (11.2)	28 (10.7)	22 (9.3)	32 (8.4)
Mood changes
Experienced	28 (42.4)	47 (39.5)	94 (55.3)	112 (42.7)	122 (51.7)	159 (41.7)
WO	8 (12.1)	12 (10.1)	44 (25.9)	47 (17.9)	52 (22.0)	59 (15.5)
Numbness
Experienced	11 (16.7)	19 (16.0)	53 (31.2)	52 (19.8)	64 (27.1)	71 (18.6)
WO	2 (3.0)	2 (1.7)	16 (9.4)	17 (6.5)	18 (7.6)	19 (5.0)
Panic attacks
Experienced	5 (7.6)	7 (5.9)	29 (17.1)	32 (12.2)	34 (14.4)	39 (10.2)
WO	1 (1.5)	1 (0.8)	11 (6.5)	9 (3.4)	12 (5.1)	10 (2.6)
Cloudy mind
Experienced	17 (25.7)	22 (18.5)	59 (34.7)	96 (36.6)	76 (32.2)	118 (31.0)
WO	4 (6.1)	3 (2.5)	21 (12.3)	41 (15.6)	25 (10.6)	44 (11.5)
Abdominal discomfort
Experienced	19 (28.8)	30 (25.2)	53 (31.2)	48 (18.3)	72 (30.5)	78 (20.5)
WO	1 (1.5)	2 (1.7)	11 (6.5)	13 (5.0)	12 (5.1)	15 (3.9)
Feelings of hot/cold
Experienced	11 (16.7)	16 (13.4)	51 (30.0)	53 (20.2)	62 (26.3)	69 (18.1)
WO	2 (3.0)	2 (1.7)	14 (8.2)	12 (4.6)	16 (6.8)	14 (3.7)
Pain
Experienced	29 (43.9)	26 (21.8)	73 (42.9)	75 (28.6)	102 (43.2)	101 (26.5)
WO	8 (12.1)	5 (4.2)	29 (17.1)	23 (8.8)	37 (15.7)	28 (7.3)
Aching
Experienced	14 (21.2)	31 (26.1)	67 (39.4)	88 (33.6)	81 (34.3)	119 (31.2)
WO	5 (7.6)	11 (9.2)	33 (19.4)	41 (15.6)	38 (16.1)	52 (13.6)