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The Scientific World Journal
Volume 2015, Article ID 816364, 6 pages
http://dx.doi.org/10.1155/2015/816364
Review Article

A Review on Pharmacological Properties of Zingerone (4-(4-Hydroxy-3-methoxyphenyl)-2-butanone)

1Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sher-e-Kashmir University of Agricultural Science & Technology (SKUAST-K), Srinagar, Jammu and Kashmir 190006, India
2Forest Biotech Lab, Department of Forest Management, Faculty of Forestry, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
3Division of Livestock Production & Management, Faculty of Veterinary Sciences & Animal Husbandry, Sher-e-Kashmir University of Agricultural Science & Technology (SKUAST-K), Srinagar, Jammu and Kashmir 190006, India

Received 26 March 2015; Accepted 18 April 2015

Academic Editor: Thomas Efferth

Copyright © 2015 Bilal Ahmad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Humans have been using natural products for medicinal use for ages. Natural products of therapeutic importance are compounds derived from plants, animals, or any microorganism. Ginger is also one of the most commonly used condiments and a natural drug in vogue. It is a traditional medicine, having some active ingredients used for the treatment of numerous diseases. During recent research on ginger, various ingredients like zingerone, shogaol, and paradol have been obtained from it. Zingerone (4-(4-hydroxy-3-methoxyphenyl)-2-butanone) is a nontoxic and inexpensive compound with varied pharmacological activities. It is the least pungent component of Zingiber officinale. Zingerone is absent in fresh ginger but cooking or heating transforms gingerol to zingerone. Zingerone closely related to vanillin from vanilla and eugenol from clove. Zingerone has potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic, and so forth properties. Besides, it displays the property of enhancing growth and immune stimulation. It behaves as appetite stimulant, anxiolytic, antithrombotic, radiation protective, and antimicrobial. Also, it inhibits the reactive nitrogen species which are important in causing Alzheimer’s disease and many other disorders. This review is written to shed light on the various pharmacological properties of zingerone and its role in alleviating numerous human and animal diseases.