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The Scientific World Journal
Volume 2015, Article ID 979560, 9 pages
http://dx.doi.org/10.1155/2015/979560
Review Article

Patient, Surgery, and Hospital Related Risk Factors for Surgical Site Infections following Total Hip Arthroplasty

1Department of Orthopaedic Surgery, Division of Adult Reconstruction and Joint Replacement, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
2Department of Anesthesiology, Perioperative Medicine and Intensive Care Medicine, Paracelsus Medical University, Muellner Hauptstrasse 48, 5020 Salzburg, Austria
3Department of Anesthesiology, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA

Received 18 September 2014; Accepted 1 January 2015

Academic Editor: Ali Hosseini

Copyright © 2015 Georgios Triantafyllopoulos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. M. Kurtz, K. L. Ong, E. Lau, and K. J. Bozic, “Impact of the economic downturn on total joint replacement demand in the United States: updated projections to 2021,” The Journal of Bone and Joint Surgery—American Volume, vol. 96, no. 8, pp. 624–630, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. K. J. Bozic, S. M. Kurtz, E. Lau et al., “The epidemiology of revision total knee arthroplasty in the united states,” Clinical Orthopaedics and Related Research, vol. 468, no. 1, pp. 45–51, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. J. D. Whitehouse, N. Deborah Friedman, K. B. Kirkland, W. J. Richardson, and D. J. Sexton, “The impact of surgical-site infections following orthopedic surgery at a community hospital and a university hospital: adverse quality of life, excess length of stay, and extra cost,” Infection Control and Hospital Epidemiology, vol. 23, no. 4, pp. 183–189, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. S. A. McGarry, J. J. Engemann, K. Schmader, D. J. Sexton, and K. S. Kaye, “Surgical-site infection due to Staphylococcus aureus among elderly patients: mortality, duration of hospitalization, and cost,” Infection Control and Hospital Epidemiology, vol. 25, no. 6, pp. 461–467, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. D. M. Urquhart, F. S. Hanna, S. L. Brennan et al., “Incidence and risk factors for deep surgical site infection after primary total hip arthroplasty: a systematic review,” Journal of Arthroplasty, vol. 25, no. 8, pp. 1216.e3–1222.e3, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Ridgeway, J. Wilson, A. Charlet, G. Katafos, A. Pearson, and R. Coello, “Infection of the surgical site after arthroplasty of the hip,” The Journal of Bone and Joint Surgery. British Volume, vol. 87, no. 6, pp. 844–850, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Wu, X. Qu, F. Liu, H. Li, Y. Mao, and Z. Zhu, “Risk factors for periprosthetic joint infection after total hip arthroplasty and total knee arthroplasty in Chinese patients,” PLoS ONE, vol. 9, no. 4, Article ID e95300, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Cordero-Ampuero and M. de Dios, “What are the risk factors for infection in hemiarthroplasties and total hip arthroplasties?” Clinical Orthopaedics and Related Research, vol. 468, no. 12, pp. 3268–3277, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. R. A. Malinzak, M. A. Ritter, M. E. Berend, J. B. Meding, E. M. Olberding, and K. E. Davis, “Morbidly obese, diabetic, younger, and unilateral joint arthroplasty patients have elevated total joint arthroplasty infection rates,” Journal of Arthroplasty, vol. 24, no. 6, supplement, pp. 84–88, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. L. A. Poultsides, Y. Ma, A. G. Della Valle, Y.-L. Chiu, T. P. Sculco, and S. G. Memtsoudis, “In-hospital surgical site infections after primary hip and knee arthroplasty—incidence and risk factors,” Journal of Arthroplasty, vol. 28, no. 3, pp. 385–389, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Dale, A. M. Fenstad, G. Hallan et al., “Increasing risk of prosthetic joint infection after total hip arthroplasty,” Acta Orthopaedica, vol. 83, no. 5, pp. 449–458, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. K. L. Ong, S. M. Kurtz, E. Lau, K. J. Bozic, D. J. Berry, and J. Parvizi, “Prosthetic joint infection risk after total hip arthroplasty in the medicare population,” Journal of Arthroplasty, vol. 24, supplement 6, pp. 105–109, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. C. A. Willis-Owen, A. Konyves, and D. K. Martin, “Factors affecting the incidence of infection in hip and knee replacement: an analysis of 5277 cases,” Journal of Bone and Joint Surgery—Series B, vol. 92, no. 8, pp. 1128–1133, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. R. S. Namba, M. C. S. Inacio, and E. W. Paxton, “Risk factors associated with surgical site infection in 30 491 primary total hip replacements,” The Journal of Bone and Joint Surgery—British Volume, vol. 94, no. 10, pp. 1330–1338, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Cooper, H. Inskip, P. Croft et al., “Individual risk factors for hip osteoarthritis: obesity, hip injury, and physical activity,” The American Journal of Epidemiology, vol. 147, no. 6, pp. 516–522, 1998. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. H. Chee, K. H. Teoh, B. M. Sabnis, J. A. Ballantyne, and I. J. Brenkel, “Total hip replacement in morbidly obese patients with osteoarthritis: results of a prospectively matched study,” The Journal of Bone and Joint Surgery—British Volume, vol. 92, no. 8, pp. 1066–1071, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Carroll, M. Dowsey, P. Choong, and T. Peel, “Risk factors for superficial wound complications in hip and knee arthroplasty,” Clinical Microbiology and Infection, vol. 20, no. 2, pp. 130–135, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. T. N. Peel, M. M. Dowsey, J. R. Daffy, P. A. Stanley, P. F. M. Choong, and K. L. Buising, “Risk factors for prosthetic hip and knee infections according to arthroplasty site,” The Journal of Hospital Infection, vol. 79, no. 2, pp. 129–133, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. K. J. Bozic, E. Lau, S. Kurtz et al., “Patient-related risk factors for periprosthetic joint infection and postoperative mortality following total hip arthroplasty in medicare patients,” Journal of Bone and Joint Surgery—Series A, vol. 94, no. 9, pp. 794–800, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. P. F. M. Choong, M. M. Dowsey, D. Carr, J. Daffy, and P. Stanley, “Risk factors associated with acute hip prosthetic joint infections and outcome of treatment with a rifampinbased regimen,” Acta Orthopaedica, vol. 78, no. 6, pp. 755–765, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. M. M. Dowsey and P. F. M. Choong, “Obesity is a major risk factor for prosthetic infection after primary hip arthroplasty,” Clinical Orthopaedics and Related Research, vol. 466, no. 1, pp. 153–158, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. R. J. Friedman, S. Hess, S. D. Berkowitz, and M. Homering, “Complication rates after hip or knee arthroplasty in morbidly obese patients,” Clinical Orthopaedics and Related Research, vol. 471, no. 10, pp. 3358–3366, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Maoz, M. Phillips, J. Bosco et al., “The Otto Aufranc award: modifiable versus nonmodifiable risk factors for infection after hip arthroplasty,” Clinical Orthopaedics and Related Research, vol. 473, no. 2, pp. 453–459, 2015. View at Publisher · View at Google Scholar
  24. B. Mraovic, D. Suh, C. Jacovides, and J. Parvizi, “Perioperative hyperglycemia and postoperative infection after lower limb arthroplasty,” Journal of Diabetes Science and Technology, vol. 5, no. 2, pp. 412–418, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Pulido, E. Ghanem, A. Joshi, J. J. Purtill, and J. Parvizi, “Periprosthetic joint infection: the incidence, timing, and predisposing factors,” Clinical Orthopaedics and Related Research, vol. 466, no. 7, pp. 1710–1715, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Font-Vizcarra, E. Tornero, G. Bori, J. Bosch, J. Mensa, and A. Soriano, “Relationship between intraoperative cultures during hip arthroplasty, obesity, and the risk of early prosthetic joint infection: a prospective study of 428 patients,” International Journal of Artificial Organs, vol. 34, no. 9, pp. 870–875, 2011. View at Google Scholar
  27. V. P. Patel, M. Walsh, B. Sehgal, C. Preston, H. DeWal, and P. E. Di Cesare, “Factors associated with prolonged wound drainage after primary total hip and knee arthroplasty,” The Journal of Bone and Joint Surgery—American Volume, vol. 89, no. 1, pp. 33–38, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Saleh, M. Olson, S. Resig et al., “Predictors of wound infection in hip and knee joint replacement: results from a 20 year surveillance program,” Journal of Orthopaedic Research, vol. 20, no. 3, pp. 506–515, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. M. C. S. Inacio, D. Kritz-Silverstein, R. Raman et al., “The impact of pre-operative weight loss on incidence of surgical site infection and readmission rates after total joint arthroplasty,” Journal of Arthroplasty, vol. 29, no. 3, pp. 458.e1–464.e1, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. M. E. E. van Kasteren, J. Manniën, A. Ott, B.-J. Kullberg, A. S. de Boer, and I. C. Gyssens, “Antibiotic prophylaxis and the risk of surgical site infections following total hip arthroplasty: timely administration is the most important factor,” Clinical Infectious Diseases, vol. 44, no. 7, pp. 921–927, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Lai, E. R. Bohm, C. Burnell, and D. R. Hedden, “Presence of medical comorbidities in patients with infected primary hip or knee arthroplasties,” Journal of Arthroplasty, vol. 22, no. 5, pp. 651–656, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. A. A. Rizvi, S. A. Chillag, and K. J. Chillag, “Perioperative management of diabetes and hyperglycemia in patients undergoing orthopaedic surgery,” Journal of the American Academy of Orthopaedic Surgeons, vol. 18, no. 7, pp. 426–435, 2010. View at Google Scholar · View at Scopus
  33. M. Turina, D. E. Fry, and H. C. Polk Jr., “Acute hyperglycemia and the innate immune system: clinical, cellular, and molecular aspects,” Critical Care Medicine, vol. 33, no. 7, pp. 1624–1633, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. K.-H. Song, E. S. Kim, Y. K. Kim et al., “Differences in the risk factors for surgical site infection between total hip arthroplasty and total knee arthroplasty in the Korean Nosocomial Infections Surveillance System (KONIS),” Infection Control and Hospital Epidemiology, vol. 33, no. 11, pp. 1086–1093, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Iorio, K. M. Williams, A. J. Marcantonio, L. M. Specht, J. F. Tilzey, and W. L. Healy, “Diabetes mellitus, hemoglobin A1C, and the incidence of total joint arthroplasty infection,” Journal of Arthroplasty, vol. 27, no. 5, pp. 726.e1–729.e1, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. M. H. Marchant Jr., N. A. Viens, C. Cook, T. P. Vail, and M. P. Bolognesi, “The impact of glycemic control and diabetes mellitus on perioperative outcomes after total joint arthroplasty,” The Journal of Bone and Joint Surgery—American volume, vol. 91, no. 7, pp. 1621–1629, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. T. Bongartz, C. S. Halligan, D. R. Osmon et al., “Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis,” Arthritis Care and Research, vol. 59, no. 12, pp. 1713–1720, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Momohara, K. Kawakami, T. Iwamoto et al., “Prosthetic joint infection after total hip or knee arthroplasty in rheumatoid arthritis patients treated with nonbiologic and biologic disease-modifying antirheumatic drugs,” Modern Rheumatology, vol. 21, no. 5, pp. 469–475, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Gilson, L. Gossec, X. Mariette et al., “Risk factors for total joint arthroplasty infection in patients receiving tumor necrosis factor α-blockers: a case-control study,” Arthritis Research and Therapy, vol. 12, no. 4, article R145, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. K. Kawakami, K. Ikari, K. Kawamura et al., “Complications and features after joint surgery in rheumatoid arthritis patients treated with tumour necrosis factor-α blockers: perioperative interruption of tumour necrosis factor-a blockers decreases complications?” Rheumatology, vol. 49, no. 2, Article ID kep376, pp. 341–347, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. A. Ruyssen-Witrand, L. Gossec, C. Salliot et al., “Complication rates of 127 surgical procedures performed in rheumatic patients receiving tumor necrosis factor alpha blockers,” Clinical and Experimental Rheumatology, vol. 25, no. 3, pp. 430–436, 2007. View at Google Scholar · View at Scopus
  42. E. F. Berbari, A. D. Hanssen, M. C. Duffy et al., “Risk factors for prosthetic joint infection: case-control study,” Clinical Infectious Diseases, vol. 27, no. 5, pp. 1247–1254, 1998. View at Publisher · View at Google Scholar · View at Scopus
  43. S. L. Jiang, W. W. Schairer, and K. J. Bozic, “Increased rates of periprosthetic joint infection in patients with cirrhosis undergoing total joint arthroplasty,” Clinical Orthopaedics and Related Research, vol. 472, no. 8, pp. 2483–2491, 2014. View at Publisher · View at Google Scholar · View at Scopus
  44. A. J. Reiffel, P. S. Barie, and J. A. Spector, “A multi-disciplinary review of the potential association between closed-suction drains and surgical site infection,” Surgical Infections, vol. 14, no. 3, pp. 244–269, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. S. M. Jafari, D. S. Casper, C. Restrepo, B. Zmistowski, J. Parvizi, and P. F. Sharkey, “Periprosthetic joint infection: are patients with multiple prosthetic joints at risk?” Journal of Arthroplasty, vol. 27, no. 6, pp. 877–880, 2012. View at Publisher · View at Google Scholar · View at Scopus
  46. E. Fulkerson, C. J. della Valle, B. Wise, M. Walsh, C. Preston, and P. E. di Cesare, “Antibiotic susceptibility of bacteria infecting total joint arthroplasty sites,” The Journal of Bone and Joint Surgery. American Volume, vol. 88, no. 6, pp. 1231–1237, 2006. View at Publisher · View at Google Scholar · View at Scopus
  47. D. M. LaPorte, B. J. Waldman, M. A. Mont, and D. S. Hungerford, “Infections associated with dental procedures in total hip arthroplasty,” The Journal of Bone and Joint Surgery—British Volume, vol. 81, no. 1, pp. 56–59, 1999. View at Publisher · View at Google Scholar · View at Scopus
  48. L. A. Poultsides, L. K. Papatheodorou, T. S. Karachalios et al., “Novel model for studying hematogenous infection in an experimental setting of implant-related infection by a community-acquired methicillin-resistant S. aureus strain,” Journal of Orthopaedic Research, vol. 26, no. 10, pp. 1355–1362, 2008. View at Publisher · View at Google Scholar · View at Scopus
  49. R. Sousa, E. Muñoz-Mahamud, J. Quayle et al., “Is asymptomatic bacteriuria a risk factor for prosthetic joint infection?” Clinical Infectious Diseases, vol. 59, no. 1, pp. 41–47, 2014. View at Publisher · View at Google Scholar
  50. J. S. Everhart, E. Altneu, and J. H. Calhoun, “Medical comorbidities are independent preoperative risk factors for surgical infection after total joint arthroplasty,” Clinical Orthopaedics and Related Research, vol. 471, no. 10, pp. 3112–3119, 2013. View at Publisher · View at Google Scholar · View at Scopus
  51. E. Murphy, S. J. Spencer, D. Young, B. Jones, and M. J. G. Blyth, “MRSA colonisation and subsequent risk of infection despite effective eradication in orthopaedic elective surgery,” Journal of Bone and Joint Surgery—British Volume, vol. 93, no. 4, pp. 548–551, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. D. H. Kim, M. Spencer, S. M. Davidson et al., “Institutional prescreening for detection and eradication of methicillin-resistant Staphylococcus aureus in patients undergoing elective orthopaedic surgery,” The Journal of Bone and Joint Surgery—American Volume, vol. 92, no. 9, pp. 1820–1826, 2010. View at Publisher · View at Google Scholar · View at Scopus
  53. E. B. Smith, R. Wynne, A. Joshi, H. Liu, and R. P. Good, “Is it time to include vancomycin for routine perioperative antibiotic prophylaxis in total joint arthroplasty patients?” The Journal of Arthroplasty, vol. 27, no. 8, supplement, pp. 55–60, 2012. View at Publisher · View at Google Scholar
  54. P. Innerhofer, A. Klingler, C. Klimmer, D. Fries, and W. Nussbaumer, “Risk for postoperative infection after transfusion of white blood cell-filtered allogeneic or autologous blood components in orthopedic patients undergoing primary arthroplasty,” Transfusion, vol. 45, no. 1, pp. 103–110, 2005. View at Publisher · View at Google Scholar · View at Scopus
  55. E. T. Newman, T. S. Watters, J. S. Lewis et al., “Impact of perioperative allogeneic and autologous blood transfusion on acute wound infection following total knee and total hip arthroplasty,” The Journal of Bone and Joint Surgery Series A, vol. 96, no. 4, pp. 279–284, 2014. View at Publisher · View at Google Scholar · View at Scopus
  56. W. H. Dzik, “Leukoreduction of blood components,” Current Opinion in Hematology, vol. 9, no. 6, pp. 521–526, 2002. View at Publisher · View at Google Scholar · View at Scopus
  57. S. G. Memtsoudis, X. Sun, Y. L. Chiu et al., “Perioperative comparative effectiveness of anesthetic technique in orthopedic patients,” Anesthesiology, vol. 118, no. 5, pp. 1046–1058, 2013. View at Publisher · View at Google Scholar · View at Scopus
  58. J. H. Park, M. R. Rasouli, S. M. J. Mortazavi, A. T. Tokarski, M. G. Maltenfort, and J. Parvizi, “Predictors of perioperative blood loss in total joint arthroplasty,” The Journal of Bone and Joint Surgery—American Volume, vol. 95, no. 19, pp. 1777–1783, 2013. View at Publisher · View at Google Scholar · View at Scopus
  59. C. J. McDougall, H. S. Gray, P. M. Simpson, S. L. Whitehouse, R. W. Crawford, and W. J. Donnelly, “Complications related to therapeutic anticoagulation in total hip arthroplasty,” The Journal of Arthroplasty, vol. 28, no. 1, pp. 187–192, 2013. View at Publisher · View at Google Scholar · View at Scopus
  60. J. Parvizi, E. Ghanem, A. Joshi, P. F. Sharkey, W. J. Hozack, and R. H. Rothman, “Does “excessive” anticoagulation predispose to periprosthetic infection?” Journal of Arthroplasty, vol. 22, no. 6, supplement 2, pp. 24–28, 2007. View at Publisher · View at Google Scholar · View at Scopus
  61. J. Parvizi, T. Gehrke, and A. F. Chen, “Proceedings of the international consensus on periprosthetic joint infection,” Bone and Joint Journal, vol. 95, no. 11, pp. 1450–1452, 2013. View at Publisher · View at Google Scholar · View at Scopus
  62. R. O. Darouiche, M. J. Wall Jr., K. M. F. Itani et al., “Chlorhexidine-alcohol versus povidone-iodine for surgical-site antisepsis,” The New England Journal of Medicine, vol. 362, no. 1, pp. 18–26, 2010. View at Publisher · View at Google Scholar · View at Scopus
  63. K. J. Bozic, K. Ong, E. Lau et al., “Risk of complication and revision total hip arthroplasty among medicare patients with different bearing surfaces,” Clinical Orthopaedics and Related Research, vol. 468, no. 9, pp. 2357–2362, 2010. View at Publisher · View at Google Scholar · View at Scopus
  64. M. E. Berend, M. A. Ritter, L. D. Harty et al., “Simultaneous bilateral versus unilateral total hip arthroplasty: an outcomes analysis,” Journal of Arthroplasty, vol. 20, no. 4, pp. 421–426, 2005. View at Publisher · View at Google Scholar · View at Scopus
  65. E. Tsiridis, G. Pavlou, J. Charity, G. Gie, and R. West, “The safety and efficacy of bilateral simultaneous total hip replacement: an analysis of 2063 cases,” The Journal of Bone and Joint Surgery—British Volume, vol. 90, no. 8, pp. 1005–1012, 2008. View at Publisher · View at Google Scholar · View at Scopus
  66. J. Liu, C. Ma, N. Elkassabany, L. A. Fleisher, and M. D. Neuman, “Neuraxial anesthesia decreases postoperative systemic infection risk compared with general anesthesia in knee arthroplasty,” Anesthesia and Analgesia, vol. 117, no. 4, pp. 1010–1016, 2013. View at Publisher · View at Google Scholar · View at Scopus
  67. A. J. Pugely, C. T. Martin, Y. Gao, S. Mendoza-Lattes, and J. J. Callaghan, “Differences in short-term complications between spinal and general anesthesia for primary total knee arthroplasty,” The Journal of Bone and Joint Surgery. American Volume, vol. 95, no. 3, pp. 193–199, 2013. View at Publisher · View at Google Scholar · View at Scopus
  68. F. Hovaguimian, C. Lysakowski, N. Elia, and M. R. Tramèr, “Effect of intraoperative high inspired oxygen fraction on surgical site infection, postoperative nausea and vomiting, and pulmonary function: systematic review and meta-analysis of randomized controlled trials,” Anesthesiology, vol. 119, no. 2, pp. 303–316, 2013. View at Publisher · View at Google Scholar · View at Scopus
  69. E. L. P. E. Geubbels, J. C. Wille, N. J. D. Nagelkerke, C. M. J. E. Vandenbroucke-Grauls, D. E. Grobbee, and A. S. de Boer, “Hospital-related determinants for surgical-site infection following hip arthroplasty,” Infection Control and Hospital Epidemiology, vol. 26, no. 5, pp. 435–441, 2005. View at Publisher · View at Google Scholar · View at Scopus
  70. J. N. Katz, N. N. Mahomed, J. A. Baron et al., “Association of hospital and surgeon procedure volume with patient-centered outcomes of total knee replacement in a population-based cohort of patients age 65 years and older,” Arthritis and Rheumatism, vol. 56, no. 2, pp. 568–574, 2007. View at Publisher · View at Google Scholar · View at Scopus
  71. J. Muilwijk, S. van den Hof, and J. C. Wille, “Associations between surgical site infection risk and hospital operation volume and surgeon operation volume among hospitals in the Dutch nosocomial infection surveillance network,” Infection Control and Hospital Epidemiology, vol. 28, no. 5, pp. 557–563, 2007. View at Publisher · View at Google Scholar · View at Scopus
  72. J. Lee, R. Singletary, K. Schmader, D. J. Anderson, M. Bolognesi, and K. S. Kaye, “Surgical site infection in the elderly following orthopaedic surgery: risk factors and outcomes,” The Journal of Bone and Joint Surgery. American Volume, vol. 88, no. 8, pp. 1705–1712, 2006. View at Publisher · View at Google Scholar · View at Scopus