Multivariate Statistical Analysis as a Supplementary Tool for Interpretation of Variations in Salivary Cortisol Level in Women with Major Depressive Disorder

Table 2

Characteristic features of four groups of patients under antidepressant therapy displayed by HCA dendrogram.

HCA cluster	Antidepressant	Number of patients	Age of patients, years	Multiplicity of hospitalization	Hospitalization period, days	Initial and final cortisol levels, ng/mL	Highest and lowest cortisol levels, ng/mL	Mean cortisol level, ng/mL	Median for cortisol level, ng/mL
Cluster Ia	TCAs	5	51	3	29	16.57–9.67	1.25–26.25	10.80	8.44
	SSRIs	9	49	2	63	17.33–4.83	2.00–31.50	8.51	6.94
	SNRIs	2	44	1	59	15.00–5.53	1.25–24.75	8.50	7.53
	SSAs	3	39	2	66	20.58–5.21	1.25–24.25	9.30	8.75
	NaSSAs	1	63	1	21	33.00–8.62	6.25–33.00	17.50	8.62
	SSREs	1	28	7	46	27.50–9.25	1.75–27.50	8.62	7.62
	Others psychoactive drugs	4	44	3	25	12.56–7.92	1.37–21.25	7.59	6.69
	Polypragmasy	3	50	2	40	11.79–2.42	1.25–15.62	5.48	6.00
Cluster Ib	TCAs	4	55	1	71	31.06–11.59	1.25–55.00	12.98	9.15
	SSRIs	7	46	2	48	32.99–11.05	1.25–49.75	11.78	7.50
	SNRIs	5	45	2	63	33.80–12.57	1.25–62.50	9.31	4.00
	SSAs	1	57	2	46	29.50–2.87	1.25–29.50	6.34	4.62
	SARIs	2	42	5	80	27.50–7.19	1.25–37.50	9.13	7.34
	SSREs	2	47	2	21	47.00–20.31	1.75–52.00	16.24	10.69
	RIMA	1	50	5	23	37.50–5.62	1.25–37.50	10.41	6.12
	Others psychoactive drugs	4	42	3	31	34.75–7.70	1.25–38.75	11.84	6.25
	Polypragmasy	9	48	3	39	38.46–5.10	1.25–46.25	9.15	7.53
Cluster II	TCAs	2	60	1	28	86.86–6.62	1.62–87.70	22.26	10.53
	SSRIs	6	49	3	46	77.59–15.71	1.25–95.00	14.19	7.62
	SNRIs	5	45	1	38	82.25–7.85	2.50–91.00	20.97	10.00
	SSAs	2	58	1	53	58.00–6.31	1.37–102.00	12.47	7.87
	Polypragmasy	2	62	5	45	76.00–9.54	2.50–95.00	20.62	8.34
Cluster III	TCAs	1	31	3	32	161.25–83.75	8.75–161.25	50.57	30.62
	SSRIs	4	48	3	35	87.44–105.00	0.25–195.00	19.55	9.06
	SNRIs	3	44	2	51	234.96–7.72	0.25–3.75	30.03	5.94
	SSAs	1	53	6	29	195.00–151.25	5.00–195.00	26.03	11.25
	SARIs	1	51	4	76	182.50–5.00	1.25–182.50	26.73	13.00
	Others psychoactive drugs	2	45	2	33	366.27–41.25	1.25–133.50	16.97	7.28