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The Scientific World Journal
Volume 2016, Article ID 2597376, 7 pages
http://dx.doi.org/10.1155/2016/2597376
Research Article

Nod2-Nodosome in a Cell-Free System: Implications in Pathogenesis and Drug Discovery for Blau Syndrome and Early-Onset Sarcoidosis

1Department of Pathology, Ehime University Proteo-Science Center and Graduate School of Medicine, Shitsukawa 454, Toon, Ehime 791-0295, Japan
2Division of Cell-Free Sciences, Ehime University Proteo-Science Center, Bunkyocho 3, Matsuyama, Ehime 790-8577, Japan
3Department of Pediatrics, Kyoto University Graduate School of Medicine, Shogoin Kawaramachi 54, Kyoto 606-8507, Japan
4Clinical Research Center, Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki 856-8562, Japan
5Department of Infection and Host Defense, Shinshu University Graduate School of Medicine, Asahi 3-1-1, Matsumoto, Nagano 390-8621, Japan
6Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Medicine, Sakamoto 1-7-1, Nagasaki 852-8501, Japan

Received 11 March 2016; Accepted 23 May 2016

Academic Editor: Rolando Cimaz

Copyright © 2016 Tomoyuki Iwasaki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Ogura, N. Inohara, A. Benito, F. F. Chen, S. Yamaoka, and G. Núñez, “Nod2, a Nod1/Apaf-1 Family member that is restricted to monocytes and activates NF-κB,” Journal of Biological Chemistry, vol. 276, no. 7, pp. 4812–4818, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. Ogura, D. K. Bonen, N. Inohara et al., “A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease,” Nature, vol. 411, no. 6837, pp. 603–606, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. J.-P. Hugot, M. Chamaillard, H. Zouali et al., “Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease,” Nature, vol. 411, no. 6837, pp. 599–603, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Inohara, L. Del Peso, T. Koseki, S. Chen, and G. Núñez, “RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis,” The Journal of Biological Chemistry, vol. 273, no. 20, pp. 12296–12300, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. J. V. McCarthy, J. Ni, and V. M. Dixit, “RIP2 is a novel NF-κB-activating and cell death-inducing kinase,” The Journal of Biological Chemistry, vol. 273, no. 27, pp. 16968–16975, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. N. Inohara, Y. Ogura, A. Fontalba et al., “Host recognition of bacterial muramyl dipeptide mediated through NOD2: implications for Crohn's disease,” Journal of Biological Chemistry, vol. 278, no. 8, pp. 5509–5512, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. S. E. Girardin, I. G. Boneca, J. Viala et al., “Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection,” The Journal of Biological Chemistry, vol. 278, no. 11, pp. 8869–8872, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Sugimoto, R. N. Germain, L. Chedid, and B. Benacerraf, “Enhancement of carrier-specific helper T cell function by the synthetic adjuvant, N-acetyl muramyl-L-alanyl-D-isoglutamine (MDP),” Journal of Immunology, vol. 120, no. 3, pp. 980–982, 1978. View at Google Scholar · View at Scopus
  9. M. Chamaillard, D. Philpott, S. E. Girardin et al., “Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 6, pp. 3455–3460, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Tanabe, M. Chamaillard, Y. Ogura et al., “Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition,” EMBO Journal, vol. 23, no. 7, pp. 1587–1597, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Kanazawa, I. Okafuji, N. Kambe et al., “Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-κB activation: common genetic etiology with Blau syndrome,” Blood, vol. 105, no. 3, pp. 1195–1197, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. E. B. Blau, “Familial granulomatous arthritis, iritis, and rash,” The Journal of Pediatrics, vol. 107, no. 5, pp. 689–693, 1985. View at Publisher · View at Google Scholar · View at Scopus
  13. Q. Yao, “Nucleotide-binding oligomerization domain containing 2: structure, function, and diseases,” Seminars in Arthritis and Rheumatism, vol. 43, no. 1, pp. 125–130, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Shen, R. Moran, K. J. Tomecki, and Q. Yao, “Granulomatous disease associated with NOD2 sequence variants and familial camptodactyly: an intermediate form of NOD2-associated diseases?” Seminars in Arthritis and Rheumatism, vol. 45, no. 3, pp. 357–360, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Biswas, Y.-J. Liu, L. Hao et al., “Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 33, pp. 14739–14744, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. I. Tattoli, L. H. Travassos, L. A. Carneiro, J. G. Magalhaes, and S. E. Girardin, “The nodosome: Nod1 and Nod2 control bacterial infections and inflammation,” Seminars in Immunopathology, vol. 29, no. 3, pp. 289–301, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. M. J. Ombrello and D. L. Kastner, “Autoinflammation in 2010: expanding clinical spectrum and broadening therapeutic horizons,” Nature Reviews Rheumatology, vol. 7, no. 2, pp. 82–84, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Miceli-Richard, S. Lesage, M. Rybojad et al., “CARD15 mutations in Blau syndrome,” Nature Genetics, vol. 29, no. 1, pp. 19–20, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. N. J. Saez and R. Vincentelli, “High-throughput expression screening and purification of recombinant proteins in E. coli,” Methods in Molecular Biology, vol. 1091, pp. 33–53, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Kaneko, Y. Ito, T. Iwasaki et al., “Reconstituted AIM2 inflammasome in cell-free system,” Journal of Immunological Methods, vol. 426, pp. 76–81, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. I. Okafuji, R. Nishikomori, N. Kanazawa et al., “Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis,” Arthritis and Rheumatism, vol. 60, no. 1, pp. 242–250, 2009. View at Publisher · View at Google Scholar · View at Scopus