Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2016, Article ID 3125283, 4 pages
http://dx.doi.org/10.1155/2016/3125283
Research Article

Psychomotor Development in Cri du Chat Syndrome: Comparison in Two Italian Cohorts with Different Rehabilitation Methods

1Department of Pediatrics, Castelli Hospital, Verbania, Italy
2Associazione Bambini Cri du Chat (ABC), S. Casciano in Val di Pesa, Florence, Italy
3Child Neuropsychiatry Unit, Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy
4Laboratory of Human Genetics, E.O. Hospital Galliera, Genova, Italy
5Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy
6Department of Molecular Medicine, University of Pavia and IRCCS, S. Matteo, Pavia, Italy

Received 9 May 2016; Accepted 28 August 2016

Academic Editor: Barbara Bardoni

Copyright © 2016 Andrea Guala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The Cri du Chat syndrome (CdC) is a rare genetic disorder caused by variable size deletions of the short arm of chromosome 5 (5p−). It is well known that home-reared patients show better performances as compared to institutionalised cases, and it was reported that continuous educational intervention can ameliorate their performances. To assess the efficacy of educational intervention and to develop new CdC oriented programs of rehabilitation, we compare the results obtained for many developmental skills in two groups of CdC patients undergoing two different rehabilitation programs. Using data on the development of a group of CdC patients obtained by validated Italian translation for the Denver Developmental Screening Test II, we compared a group of 13 patients undergoing an educational program developed for CdC patients, the Mayer Project (MP), with a second group of 15 cases in whom caring was not specifically oriented. A positive impact of the MP was reported by parents, observing an improvement in social skills obtained, even if no significant differences were observed when the items of the Denver Test are studied. The need for personalized care in CdC patients and the choice of different methods to compare the results are also discussed.