Punica granatum L. (Pomegranate) Extract: In Vivo Study of Antimicrobial Activity against Porphyromonas gingivalis in Galleria mellonella Model

Figure 1

Survival curve of G. mellonella with glycolic extract of pomegranate. Different concentrations of PGE (200 mg/mL, 100 mg/mL, 25 mg/mL, 12.5 mg/mL, 6.25 mg/mL, 3.1 mg/mL, and 2.5 mg/mL) diluted in PBS were inoculated in the last proleg of each larva. Fifteen larvae were used per group. The number of dead G. mellonella was daily recorded for 168 hours for analysis of the survival curve. Injection of high concentration (200, 100, and 25 mg/mL) of PGE showed a toxic effect, leading G. mellonella to death.