Cancer Is to Embryology as Mutation Is to Genetics: Hypothesis of the Cancer as Embryological Phenomenon

Figure 2

Differences established during gastrulation through the EMT and MET processes. The EMT and MET processes involve a specific transcriptional regulation and they are responsible for simultaneously orchestrating processes of proliferation, migration, cell differentiation, and invasion. However, these programs are different depending on the embryonic layer of origin. The arrowhead or arrow indicates the “intensity” of the regulation.