Research Article

Gabapentin Inhibits Protein Kinase C Epsilon Translocation in Cultured Sensory Neurons with Additive Effects When Coapplied with Paracetamol (Acetaminophen)

Figure 1

Confocal optical sections of cultured sensory neurons treated with prokineticin 2 (100 nM) for 30 seconds and subsequently fixed and stained for PKCɛ with a polyclonal specific antibody. Nuclei were stained in blue with DAPI. The largest neuron is showing translocation of PKCɛ to the plasma membrane; the smaller neurons represent a typical example of nontranslocated neurons. Translocation induced by 1 μM bradykinin (BK) for 30 seconds had identical appearance. Scale bar: 5 μm.