The Scientific World Journal / 2017 / Article / Fig 2

Research Article

Gabapentin Inhibits Protein Kinase C Epsilon Translocation in Cultured Sensory Neurons with Additive Effects When Coapplied with Paracetamol (Acetaminophen)

Figure 2

PKC translocation induced by bradykinin and PK2 is dose-dependently inhibited by gabapentin. (a) Gabapentin dose-response data on bradykinin-induced (white square symbols) and PK2-induced translocation (white circles). Gabapentin was preapplied for 5 minutes, and then neurons were treated with 1 μM bradykinin or 100 nM PK2 for 30 s in the presence of the same preapplied concentration. (b) Time course of translocation at different times in control culture medium (black symbols) and in the same medium with 200 μM gabapentin added (white symbols). Both bradykinin- and PK2-induced translocation and gabapentin effect are not time-dependent in these conditions. See Results for further details. Notes: values are means ± SEM of data from 4–7 separate cultures.
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