Gabapentin Inhibits Protein Kinase C Epsilon Translocation in Cultured Sensory Neurons with Additive Effects When Coapplied with Paracetamol (Acetaminophen)

<div>PKC translocation induced by bradykinin and PK2 is dose-dependently inhibited by gabapentin. (a) Gabapentin dose-response data on bradykinin-induced (white square symbols) and PK2-induced translocation (white circles). Gabapentin was preapplied for 5 minutes, and then neurons were treated with 1 <i>μ</i>M bradykinin or 100 nM PK2 for 30 s in the presence of the same preapplied concentration. (b) Time course of translocation at different times in control culture medium (black symbols) and in the same medium with 200 <i>μ</i>M gabapentin added (white symbols). Both bradykinin- and PK2-induced translocation and gabapentin effect are not time-dependent in these conditions. See Results for further details. Notes: values are means ± SEM of data from 4–7 separate cultures.</div>

The Scientific World Journal

fig2

Figure 2

Figure 2: Gabapentin Inhibits Protein Kinase C Epsilon Translocation in Cultured Sensory Neurons with Additive Effects When Coapplied with Paracetamol (Acetaminophen) 

Figure 2 | Gabapentin Inhibits Protein Kinase C Epsilon Translocation in Cultured Sensory Neurons with Additive Effects When Coapplied with Paracetamol (Acetaminophen) 